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The aim of the study was to compare a set of plasma humoral factors, age and body mass index between normotensive sons from hypertensive (SH, n=101) and normotensive (SN, n=100) families. The sons were at the age of 18-40 years. Comparing individual variables, the significant differences were found in basal adrenalin load, noradrenalin before (basal) and after glucose load, basal dopamine, basal endothelin and fibrinogen between SH and SN. Moreover, SH was significantly older by two years than SN. The linear discriminant analysis and neutral network were applied to find the best classifying variables between SH and SN. Basal noradrenalin, fibrinogen, basal glycemia and age were the best discriminating variables between SH and SN using the discriminant analysis. The neural network used, in addition, basal aldosterone, relative plasma viscosity, glycated hemoglobin to estimate family status (SH or SN). There were no essential differences between those methods in predicting family status in the test set (66% of correct classification), even if the results in the training set were far better for the neural network (83% of correct classification) than for the discriminant analysis (69% of correct classification). Simultaneous using of several humoral factors can serve as intermediate phenotype that could improve identification of hypertension.
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