Disastrous circumstances such as radiation and nuclear meltdown require a large and complex scale of emergency health and social care capacity planning framework. Devastating issues and challenges of incompleteness, inconsistency, and the infeasibility of provided requirements of the suggested planning framework might create unnecessary conflicts during the system development. In this paper, we proposed requirements engineering of an emergency preparedness and response simulation model (EPRM) for Malaysia Radiation and Nuclear (MRN) emergency plan simulator. This simulator is expected to plan and manage emergencies and disasters included the risk involved when the nuclear reactor is malfunctioning due to natural disasters such as floods, earthquake, and cyber-attacks. We identify the social and technical problems of implementing the emergencies and disasters policies and also the critical and safety of software systems use to run the nuclear plants. We simulate the proposed emergency preparedness and response model (EPRM) through the simulation software. Finally, we measure the effectiveness of the proposed model using thematic synthesis and qualitative regression analysis provided outstandingly sociotechnical aspects of the affected junctures under investigation. From the testing of the proposed model, we found that if the organization is not able to define and identify, the disaster coordinator roles and responsibility, resources and equipment may contribute 65.63% of emergency plan disorder and severe calamities towards first responders, operators, workers, patients and community at large. Also, we found that those themes were to bone up the main simulation workflow diagram. This finding supported and correlated independently towards Information Systems Development (ISD) key concepts by 13.30 (T value). Those themes were confirmed and reliable coherently (average 89% degree) rather than by chance. Finally, the proposed emergency preparedness and response model (EPRM) that is the theory building methods integrated technical and analytical procedures in a sociotechnical outlook. These methods established on developing emergency response perquisites rather than intervention principles alone. Most likely, this approach was significantly useful to justify a mixture of tacit and explicit knowledge among the emergency plan expertise. Consequently, a strategized, simplified and prevailing RANEP simulator can be achieved, though it is certainly as complex.