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Complexity and Modularity of MAPK Signaling Networks

Complexity and Modularity of MAPK Signaling Networks

George V. Popescu, Sorina C. Popescu
Copyright: © 2011 |Pages: 14
ISBN13: 9781609604912|ISBN10: 1609604911|EISBN13: 9781609604929
DOI: 10.4018/978-1-60960-491-2.ch016
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MLA

Popescu, George V., and Sorina C. Popescu. "Complexity and Modularity of MAPK Signaling Networks." Handbook of Research on Computational and Systems Biology: Interdisciplinary Applications, edited by Limin Angela Liu, et al., IGI Global, 2011, pp. 355-368. https://doi.org/10.4018/978-1-60960-491-2.ch016

APA

Popescu, G. V. & Popescu, S. C. (2011). Complexity and Modularity of MAPK Signaling Networks. In L. Liu, D. Wei, Y. Li, & H. Lei (Eds.), Handbook of Research on Computational and Systems Biology: Interdisciplinary Applications (pp. 355-368). IGI Global. https://doi.org/10.4018/978-1-60960-491-2.ch016

Chicago

Popescu, George V., and Sorina C. Popescu. "Complexity and Modularity of MAPK Signaling Networks." In Handbook of Research on Computational and Systems Biology: Interdisciplinary Applications, edited by Limin Angela Liu, et al., 355-368. Hershey, PA: IGI Global, 2011. https://doi.org/10.4018/978-1-60960-491-2.ch016

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Abstract

Signaling through mitogen-activated protein kinase (MAPK) cascades is a conserved and fundamental process in all eukaryotes. This chapter reviews recent progress made in the identification of components of MAPK signaling networks using novel large scale experimental methods. It also presents recent landmarks in the computational modeling and simulation of the dynamics of MAPK signaling modules. The in vitro MAPK signaling network reconstructed from predicted phosphorylation events is dense, supporting the hypothesis of a combinatorial control of transcription through selective phosphorylation of sets of transcription factors. Despite the fact that additional co-factors and scaffold proteins may regulate the dynamics of signal transduction in vivo, the complexity of MAPK signaling networks supports a new model that departs significantly from that of the classical definition of a MAPK cascade.

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