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Dis2PPI: A Workflow Designed to Integrate Proteomic and Genetic Disease Data

Dis2PPI: A Workflow Designed to Integrate Proteomic and Genetic Disease Data

Daniel Luis Notari, Samuel Brando Oldra, Mauricio Adami Mariani, Cristian Reolon, Diego Bonatto
Copyright: © 2012 |Volume: 3 |Issue: 3 |Pages: 19
ISSN: 1947-9115|EISSN: 1947-9123|EISBN13: 9781466613232|DOI: 10.4018/jkdb.2012070104
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MLA

Notari, Daniel Luis, et al. "Dis2PPI: A Workflow Designed to Integrate Proteomic and Genetic Disease Data." IJKDB vol.3, no.3 2012: pp.67-85. http://doi.org/10.4018/jkdb.2012070104

APA

Notari, D. L., Oldra, S. B., Mariani, M. A., Reolon, C., & Bonatto, D. (2012). Dis2PPI: A Workflow Designed to Integrate Proteomic and Genetic Disease Data. International Journal of Knowledge Discovery in Bioinformatics (IJKDB), 3(3), 67-85. http://doi.org/10.4018/jkdb.2012070104

Chicago

Notari, Daniel Luis, et al. "Dis2PPI: A Workflow Designed to Integrate Proteomic and Genetic Disease Data," International Journal of Knowledge Discovery in Bioinformatics (IJKDB) 3, no.3: 67-85. http://doi.org/10.4018/jkdb.2012070104

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Abstract

Experiments in bioinformatics are based on protocols that employ different steps for data mining and data integration, collectively known as computational workflows. Considering the use of databases in the biomedical sciences software that is able to query multiple databases is desirable. Systems biology, which encompasses the design of interactomic networks to understand complex biological processes, can benefit from computational workflows. Unfortunately, the use of computational workflows in systems biology is still very limited, especially for applications associated with the study of disease. To address this limitation, we designed Dis2PPI, a workflow that integrates information retrieved from genetic disease databases and interactomes. Dis2PPI extracts protein names from a disease report and uses this information to mine protein-protein interaction (PPI) networks. The data gathered from this mining can be used in systems biology analyses. To demonstrate the functionality of Dis2PPI for systems biology analyses, the authors mined information about xeroderma pigmentosum and Cockayne syndrome, two monogenic diseases that lead to skin cancer when the patients are exposed to sunlight and neurodegeneration.

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