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Characterization and Classification of Local Protein Surfaces Using Self-Organizing Map

Characterization and Classification of Local Protein Surfaces Using Self-Organizing Map

Lee Sael, Daisuke Kihara
Copyright: © 2010 |Volume: 1 |Issue: 1 |Pages: 16
ISSN: 1947-9115|EISSN: 1947-9123|ISSN: 1947-9115|EISBN13: 9781616929923|EISSN: 1947-9123|DOI: 10.4018/jkdb.2010100203
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MLA

Sael, Lee, and Daisuke Kihara. "Characterization and Classification of Local Protein Surfaces Using Self-Organizing Map." IJKDB vol.1, no.1 2010: pp.32-47. http://doi.org/10.4018/jkdb.2010100203

APA

Sael, L. & Kihara, D. (2010). Characterization and Classification of Local Protein Surfaces Using Self-Organizing Map. International Journal of Knowledge Discovery in Bioinformatics (IJKDB), 1(1), 32-47. http://doi.org/10.4018/jkdb.2010100203

Chicago

Sael, Lee, and Daisuke Kihara. "Characterization and Classification of Local Protein Surfaces Using Self-Organizing Map," International Journal of Knowledge Discovery in Bioinformatics (IJKDB) 1, no.1: 32-47. http://doi.org/10.4018/jkdb.2010100203

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Abstract

Annotating protein structures is an urgent task as increasing number of protein structures of unknown function is being solved. To achieve this goal, it is critical to establish computational methods for characterizing and classifying protein local structures. The authors analyzed the similarity of local surface patches from 609 representative proteins considering shape and the electrostatic potential, which are represented by the 3D Zernike descriptors. Classification of local patches is done with the emergent self-organizing map (ESOM). They mapped patches at ligand binding-sites to investigate how they distribute and cluster among the ESOM map. They obtained 30-50 clusters of local surfaces of different characteristics, which will be useful for annotating surface of proteins.

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