Author:
Hadar Ben-Yoav
Affiliation:
Ben-Gurion University of the Negev, Israel
Keyword(s):
Electrochemical Sensors, Lab-on-a-Chip, Intelligent Sensors, Chemometrics, Redox, Biomedical Diagnostics.
Abstract:
Redox molecules play an essential role in many biological pathways, including energy metabolism, biosynthesis, and cell respiration. Moreover, a specific spectrum of redox molecules (comprising their type, concentration, and redox state) is involved in the development of diseases, including cancer. Thus, profiling the redox spectrum in the body is highly beneficial for a wide range of biomedical applications, from in vivo diagnostics to in situ monitoring of cell metabolism. Yet, the fundamental challenge lies within the ability to efficiently extract and analyze physiologically and medically relevant information from redox molecules in biofluids. This paper will discuss the advantageous approach to rapidly and continuously monitor redox molecules in biofluids using electrochemical lab-on-a-chip biodevices. The current approaches will be discussed to selectively measure redox molecules from biofluids without diminishing the rapid and continuous monitoring capabilities of these transl
ational biodevices, i.e., by simultaneously analyzing multiple diagnostic redox biomarkers in a stand-alone operation, without any sample pretreatment or elimination of other interfering molecules. Then, the promising approach of using intelligent multi-sensor arrays will be highlighted for the rapid detection of a spectrum of redox molecules and the current challenges impeding their important utilization for next generation biomedical diagnostic devices.
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