loading
Papers Papers/2022 Papers Papers/2022

Research.Publish.Connect.

Paper

Paper Unlock

Authors: Roberta Gori ; Paolo Milazzo and Lucia Nasti

Affiliation: Dipartimento di Informatica, Università di Pisa, Largo Bruno Pontecorvo, Pisa, Italia

Keyword(s): Chemical Reaction Network, ODEs, Monotonicity.

Abstract: One of the main goals of systems biology is to understand the behaviour of (bio)chemical reaction networks, which can be very complex and difficult to analyze. Often, dynamical properties of reaction networks are studied by performing simulations based on the Ordinary Differential Equations (ODEs) models of the reactions’ kinetics. For some kinds of dynamical properties (e.g. robustness) simulations have to be repeated many times by varying the initial concentration of some components of interest. In this work, we propose sufficient conditions that guarantee the existence of monotonicity relationships between the variation of the initial concentration of an “input” biochemical species and the concentration (at all times) of an “output” species involved in the same reaction network. Our sufficient conditions allow monotonicity properties to be verified efficiently by exploring a dependency graph constructed on the set of species of the reaction network. Once established, monotonicity allows us to drastically restrict the number of simulations required to prove dynamical properties of the chemical reaction network. (More)

CC BY-NC-ND 4.0

Sign In Guest: Register as new SciTePress user now for free.

Sign In SciTePress user: please login.

PDF ImageMy Papers

You are not signed in, therefore limits apply to your IP address 18.217.228.35

In the current month:
Recent papers: 100 available of 100 total
2+ years older papers: 200 available of 200 total

Paper citation in several formats:
Gori, R.; Milazzo, P. and Nasti, L. (2019). Towards an Efficient Verification Method for Monotonicity Properties of Chemical Reaction Networks. In Proceedings of the 12th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2019) - BIOINFORMATICS; ISBN 978-989-758-353-7; ISSN 2184-4305, SciTePress, pages 250-257. DOI: 10.5220/0007522002500257

@conference{bioinformatics19,
author={Roberta Gori. and Paolo Milazzo. and Lucia Nasti.},
title={Towards an Efficient Verification Method for Monotonicity Properties of Chemical Reaction Networks},
booktitle={Proceedings of the 12th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2019) - BIOINFORMATICS},
year={2019},
pages={250-257},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0007522002500257},
isbn={978-989-758-353-7},
issn={2184-4305},
}

TY - CONF

JO - Proceedings of the 12th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2019) - BIOINFORMATICS
TI - Towards an Efficient Verification Method for Monotonicity Properties of Chemical Reaction Networks
SN - 978-989-758-353-7
IS - 2184-4305
AU - Gori, R.
AU - Milazzo, P.
AU - Nasti, L.
PY - 2019
SP - 250
EP - 257
DO - 10.5220/0007522002500257
PB - SciTePress

- Science and Technology Publications, Lda.
RESOURCES

Proceedings

Papers

Authors

Ontology

CONTACTS

Science and Technology Publications, Lda
Avenida de S. Francisco Xavier, Lote 7 Cv. C,
2900-616 Setúbal, Portugal.

Phone: +351 265 520 185 (National fixed network call)
Fax: +351 265 520 186
Email: info@scitepress.org

EXTERNAL LINKS

PRIMORIS

INSTICC

SCITEVENTS

CROSSREF

PROCEEDINGS SUBMITTED FOR INDEXATION BY:

dblp

Ei Compendex

SCOPUS

Semantic Scholar

Google Scholar

Microsoft Academic