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Authors: Hsin-Ting Chung 1 and Yuh-Jyh Hu 1 ; 2

Affiliations: 1 Institute of Biomedical Engineering, National Chiao Tung University, 1001 University Rd., Hsinchu, Taiwan ; 2 College of Computer Science, National Chiao Tung University, 1001 University Rd., Hsinchu, Taiwan

Keyword(s): Influenza A Viruses, Evolution, Mutation, Simulation.

Abstract: We propose a simulation approach for analyzing and predicting the evolution of influenza A viruses (IAVs). The simulation is conducted in a sequence-based space to constrain the evolutionary trends within a grid of clusters of protein sequences. The simulated trajectories enable the investigation into point mutations on a protein strain of IAVs in evolution, which cannot be accomplished easily by analyses of phylogenetic trees. We tested the simulation model on three IAV internal proteins, NP, PB1 and PB2. The produced evolutionary pathways were consistent with previous studies of the reassortment history of the 2009 human pandemic. In addition, the chronological analysis of host-associated signature mutations on NP, PB1 and PB2 also agreed with the previous findings.

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Paper citation in several formats:
Chung, H. and Hu, Y. (2020). A Grid-based Simulation Model for the Evolution of Influenza A Viruses. In Proceedings of the 13th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2020) - BIOINFORMATICS; ISBN 978-989-758-398-8; ISSN 2184-4305, SciTePress, pages 109-116. DOI: 10.5220/0008878401090116

@conference{bioinformatics20,
author={Hsin{-}Ting Chung. and Yuh{-}Jyh Hu.},
title={A Grid-based Simulation Model for the Evolution of Influenza A Viruses},
booktitle={Proceedings of the 13th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2020) - BIOINFORMATICS},
year={2020},
pages={109-116},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008878401090116},
isbn={978-989-758-398-8},
issn={2184-4305},
}

TY - CONF

JO - Proceedings of the 13th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2020) - BIOINFORMATICS
TI - A Grid-based Simulation Model for the Evolution of Influenza A Viruses
SN - 978-989-758-398-8
IS - 2184-4305
AU - Chung, H.
AU - Hu, Y.
PY - 2020
SP - 109
EP - 116
DO - 10.5220/0008878401090116
PB - SciTePress

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