Authors:
A. S. Fokin
;
M. L. Pospelova
;
G. E. Trufanov
;
A. V. Medenikov
;
E. D. Vyshedkevich
;
I. A. Mashchenko
;
T. M. Bukkieva
;
D. S. Chegina
;
E. A. Gorbunova
;
T. A. Alekseeva
and
A. S. Lepekhina
Affiliation:
MRI Department, Almazov National Medical Research Centre, Akkuratova str., 2, Saint-Petersburg, Russia Federation
Keyword(s):
Chronic Tension-type Headache, Osteopathic Correction, Functional MRI at Rest, Connectome.
Abstract:
Clinical and neuroimaging comparison of the dynamics of changes in the pain connectome against the background of osteopathic correction in patients with chronic tension-type headaches. We examined 24 patients with chronic tension type headaches, aged 24 to 43 years. Patients underwent resting-state functional MRI before and after first osteopathic manipulation. Complaints were evaluated and patients were surveyed to assess the intensity of headache and its impact on different areas of life, quality of life, situational and personal anxiety before and after therapy. Changes in the functional connectivity of the in patients with tension headaches after osteopathic manipulation were found to correlate with a positive clinical picture. Changes in the functional connections of the medial prefrontal cortex with other areas of the brain were detected in patients with chronic tension-type headaches when using a single osteopathic correction. There was an improvement in the condition of patie
nts both in the subjective assessment of complaints and in the objective assessment of their condition on scales. The use of methods for statistical analysis of neuroimaging data, in particular resting-state functiontional MRI, made it possible to see the differences objectively by mapping different colors using color scales, which greatly simplifies the entire analytical process. Clinical and neuroimaging comparison of the dynamics of changes in the pain connectome against the background of osteopathic correction in patients with chronic tension-type headaches provides potentially new approaches to the diagnosis and treatment of pain syndrome.
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