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Authors: Mariemme Keilsy D. Martos and Marineil C. Gomez

Affiliation: School of Chemical, Biological, Material Engineering and Sciences, Mapua University, Muralla St. Intramuros, Manila 1002, Philippines

Keyword(s): Renal Cell Cancer, Chromophobe Renal Cell Cancer Birt-Hogg-Dube Syndrome.

Abstract: CrRCC (chromophobe renal cell cancer) belongs to the group of non-clear cell cancer which accounts 4%-5% of RCC. Birt-Hogg-Dube Syndrome (BHDS), a subtype for crRCC, occurs due to the germline mutation of Folliculin (FLCN). Each disease has designated treatment and contrasting prognosis, but the histological features of this syndrome may overlap with the other subtypes of RCC which makes it difficult to differentiate and it has a limited amount of information available due to its uncommonness. This study aims to differentiate the pathway and genes involved in BHDS disease through NetworkAnalyst. The dataset was gathered from ArrayExpress and generated 395 significant DEGs in BHDS, which was then used to produce a pathway enrichment network and protein-protein interaction (PPI). Cytoskeletal protein binding correlating with hub genes KIT, RHOB, and UBC in BHDS indicates that this disease has a high risk for cell metastasis. This study gives a new promising therapeutic target for the s aid disease. (More)

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Paper citation in several formats:
Martos, M. and Gomez, M. (2022). Bioinformatics Analysis of Gene Targets for Birt-Hogg-Dube Syndrome Associated with Renal Cell Cancer using NetworkAnalyst. In Proceedings of the 15th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2022) - BIOINFORMATICS; ISBN 978-989-758-552-4; ISSN 2184-4305, SciTePress, pages 73-80. DOI: 10.5220/0010767400003123

@conference{bioinformatics22,
author={Mariemme Keilsy D. Martos. and Marineil C. Gomez.},
title={Bioinformatics Analysis of Gene Targets for Birt-Hogg-Dube Syndrome Associated with Renal Cell Cancer using NetworkAnalyst},
booktitle={Proceedings of the 15th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2022) - BIOINFORMATICS},
year={2022},
pages={73-80},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010767400003123},
isbn={978-989-758-552-4},
issn={2184-4305},
}

TY - CONF

JO - Proceedings of the 15th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2022) - BIOINFORMATICS
TI - Bioinformatics Analysis of Gene Targets for Birt-Hogg-Dube Syndrome Associated with Renal Cell Cancer using NetworkAnalyst
SN - 978-989-758-552-4
IS - 2184-4305
AU - Martos, M.
AU - Gomez, M.
PY - 2022
SP - 73
EP - 80
DO - 10.5220/0010767400003123
PB - SciTePress

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