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Amino Acid Sequence Control of the Folding of the Parallel β-Helix, the Simplest β-Sheet Fold

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Research in Computational Molecular Biology (RECOMB 2005)

Part of the book series: Lecture Notes in Computer Science ((LNBI,volume 3500))

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Abstract

Deciphering how amino acid sequences direct polypeptide chains into their native folds remains a major unsolved problem. The most refractory aspect has been understanding the pathways and sequence control of β-sheet folding. This presumably reflects in part that residues that are far apart in the sequence will be intimately interacting in the folded β-structure.

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References

  1. Betts, S., King, J.: There’s a right way and a wrong way: in vivo and in vitro folding, misfolding and subunit assembly of the P22 tailspike. Structure Fold Des. 7, R131–R139 (1999)

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  2. Bradley, P., Cowen, L., Menke, M., King, J., Berger, B.: BETAWRAP: Successful prediction of parallel β-helices from primary sequence reveals an association with many microbial pathogens. Proc. Natl. Acad. Sci. USA 98, 14819–14824 (2001)

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Authors and Affiliations

  1. Department of Biology, MIT, Cambridge, Massachusetts, USA

    Jonathan King, Cammie Haase-Pettingell, Ryan Simkovsky & Peter Weigele

Authors
  1. Jonathan King
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  2. Cammie Haase-Pettingell
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  3. Ryan Simkovsky
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  4. Peter Weigele
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Editor information

Editors and Affiliations

  1. Human Genome Center, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, 108-8639, Minato-ku, Tokyo, Japan

    Satoru Miyano

  2. Broad Institute of MIT and Harvard, 320 Charles Street, 02141-2023, Cambridge, MA, USA

    Jill Mesirov

  3. Computational Genomics Laboratory, Department of Bioengineering, Boston University, 44 Cummington St., 02215, Boston, MA, USA

    Simon Kasif

  4. Center for Molecular Biology and Computer Sciecne Department, Brown University, 115 Waterman St., 02912, Providence, RI, USA

    Sorin Istrail

  5. University of California, San Diego, USA

    Pavel A. Pevzner

  6. Department of Molecular and Computational Biology, University of Southern California, 1050 Childs Way, 90089-2910, Los Angeles, CA, USA

    Michael Waterman

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© 2005 Springer-Verlag Berlin Heidelberg

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King, J., Haase-Pettingell, C., Simkovsky, R., Weigele, P. (2005). Amino Acid Sequence Control of the Folding of the Parallel β-Helix, the Simplest β-Sheet Fold. In: Miyano, S., Mesirov, J., Kasif, S., Istrail, S., Pevzner, P.A., Waterman, M. (eds) Research in Computational Molecular Biology. RECOMB 2005. Lecture Notes in Computer Science(), vol 3500. Springer, Berlin, Heidelberg. https://doi.org/10.1007/11415770_35

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  • DOI: https://doi.org/10.1007/11415770_35

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-25866-7

  • Online ISBN: 978-3-540-31950-4

  • eBook Packages: Computer ScienceComputer Science (R0)

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