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Magnetocardiographic Imaging of Ventricular Repolarization in Rett Syndrome

  • Conference paper
Functional Imaging and Modeling of the Heart (FIMH 2005)

Part of the book series: Lecture Notes in Computer Science ((LNTCS,volume 3504))

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Abstract

Rett syndrome (RS) is a severe neurological disorder, predominant in females, with higher risk of sudden death (SD). So far for risk-assessment, heart rate variability (HRV), QT duration and its dispersion (QTd) were measured with ECG. However SD has occurred in RS also in absence of ECG abnormality. We aimed to evaluate the feasibility of magnetocardiographic (MCG) mapping as an alternative to study ventricular repolarization (VR) alteration in RS patients. 9 female (age: 1-34 years) RS patients were studied with an unshielded 36-channels MCG system. To assess VR, heart rate (HR)-corrected JTpeak, JTend, QTend, Tpeak − − endintervals and QTd, were measured from both MCG and ECG signals. Moreover the magnetic field (MF) gradient orientation (α-angle) during the ST segment and three MF dynamic parameters were automatically evaluated from MCG T-wave. HRV parameters were evaluated from 12-lead Holter ECG. 15 age-matched normal controls (NC) were studied for comparison. HR-corrected JTpeak, JTend, QTend and Tpeak − − end intervals, and QTd were longer in RS than in NC. The differences were more evident with clinical impairment (stage IV). MF gradient orientation and MF dynamic parameters were abnormal in RS patients. As compared to NC, HRV parameters were altered in the time-domain, although still within normal range in the frequency-domain. In RS, ECG recordings are often noisy and BSPM is difficult. On the contrary MCG mapping is easily feasible and discovers VR alteration not evident at the ECG. The diagnostic value of MCG in RS remains to be defined.

The research work was partially supported by MIUR grants # 9906571299_001, 2001064829_001, and by Sigma-Tau S.p.A. grant DS/2001/CR/#39. No conflict of interest.

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Author information

Authors and Affiliations

  1. Clinical Physiology–Biomagnetism Center, Catholic University of Rome, Italy

    Donatella Brisinda, Anna Maria Meloni & Riccardo Fenici

  2. Department of Child Neurology and Psychiatry, University of Siena, Italy

    Giuseppe Hayek

  3. Sigma Tau S.p.A., Rome, Italy

    Menotti Calvani

Authors
  1. Donatella Brisinda
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  2. Anna Maria Meloni
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  3. Giuseppe Hayek
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  4. Menotti Calvani
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  5. Riccardo Fenici
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Editor information

Editors and Affiliations

  1. Computational Imaging Lab, Department of Technology - D.326, Pompeu Fabra University, Barcelona, Spain

    Alejandro F. Frangi

  2. Computer Vision Center, Campus UAB, Edifici O, 08193, Bellaterra, Spain, Dept. Matemàtica Aplicada i Anàlisi, Universitat de Barcelona, Gran Via 585, 08007, Barcelona, Spain

    Petia I. Radeva

  3. School of Engineering in Telecommunication, Polytechnic University of Madrid, 28040, Madrid, Spain

    Andres Santos

  4. GTC, Aragon Institute of Engineering Research (I3A), University of Zaragoza, Spain

    Monica Hernandez

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© 2005 Springer-Verlag Berlin Heidelberg

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Brisinda, D., Meloni, A.M., Hayek, G., Calvani, M., Fenici, R. (2005). Magnetocardiographic Imaging of Ventricular Repolarization in Rett Syndrome. In: Frangi, A.F., Radeva, P.I., Santos, A., Hernandez, M. (eds) Functional Imaging and Modeling of the Heart. FIMH 2005. Lecture Notes in Computer Science, vol 3504. Springer, Berlin, Heidelberg. https://doi.org/10.1007/11494621_21

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  • DOI: https://doi.org/10.1007/11494621_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-26161-2

  • Online ISBN: 978-3-540-32081-4

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