Abstract
Spreading depression is an inactivating wave of massive cell depolarization that moves slowly through the brain associated to large negative DC potentials. Its biophysical nature is unclear. Based on our recent finding that longitudinal depolarizing gradients arise on individual neurons affected by SD, we have initiated the construction of an integral model to reproduce large macroscopic potentials in the extracellular space from channel activity on individual neurons. The model includes a simulation of the extracellular space and features V o feedback to calculate transmembrane currents and potentials.
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Leão, A.A.P.: Spreading depression of activity in the cerebral cortex. J. Neurophysiol. 7, 359–390 (1944)
Somjen, G.G.: Mechanisms of spreading depression and hypoxic spreading depression-like depolarization. Physiol. Rev. 81, 1065–1096 (2001)
Sugaya, E., Takato, M., Noda, Y.: Neuronal and glial activity during spreading depression in cerebral cortex of cat. J. Neurophysiol. 38, 822–841 (1975)
Largo, C., Cuevas, P., Somjen, G.G., Martín del Río, R., Herreras, O.: The effect of depressing glial function on rat brain in situ on ion homeostasis, synaptic transmission and neuronal survival. J. Neurosci. 16, 1219–1229 (1996)
Largo, C., Ibarz, J.M., Herreras, O.: Effects of the gliotoxin fluorocitrate on spreading depression and glial membrane potential in rat brain in situ. J. Neurophysiol. 78, 295–307 (1997)
Herreras, O., Somjen, G.G.: Analysis of potentials shifts associated with recurrent spreading depression and prolonged unstable SD induced by microdialysis of elevated K + in hippocampus of anesthetized rats. Brain Res. 610, 283–294 (1993)
Canals, S., Makarova, I., López-Aguado, L., Largo, C., Ibarz, J.M., Herreras, O.: Longitudinal depolarization gradients along the somatodendritic axis of CA1 pyramidal cells: a novel feature of spreading depression. J. Neurophysiol. (2005) in press
Ibarz, J.M., Herreras, O.: A study of the action potential initiation site along the axosomatodendritic axis of neurons using compartmental models. LNCS, vol. 2626, pp. 9–15 (2003)
Varona, P., Ibarz, J.M., López-Aguado, L., Herreras, O.: Macroscopic and subcellular factors shaping CA1 population spikes. J. Neurophysiol. 83, 2192–2208 (2000)
Makarova, I., Ibarz, J.M., López-Aguado, L., Herreras, O.: Selective Inactivation of Neuronal Dendritic Domains: Computational Approach to Steady Potential Gradients. LNCS, vol. 2626, pp. 40–45 (2003)
Czéh, G., Aitken, P.G., Somjen, G.G.: Membrane currents in CA1 pyramidal cells during spreading depression (SD) and SD-like hypoxic depolarization. Brain Res. 632, 195–208 (1993)
Kager, H., Wadman, W.J., Somjen, G.G.: Simulated seizures and spreading depression in a model incorporating interstitial space and ion concentrations. J. Neurophysiol. 84, 495–512 (2000)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2005 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Makarova, I., Cepeda, I.R., Panetsos, F., Herreras, O. (2005). An Integral Model of Spreading Depression: From Neuron Channels to Field Potentials. In: Mira, J., Álvarez, J.R. (eds) Mechanisms, Symbols, and Models Underlying Cognition. IWINAC 2005. Lecture Notes in Computer Science, vol 3561. Springer, Berlin, Heidelberg. https://doi.org/10.1007/11499220_12
Download citation
DOI: https://doi.org/10.1007/11499220_12
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-26298-5
Online ISBN: 978-3-540-31672-5
eBook Packages: Computer ScienceComputer Science (R0)