Abstract
Deformation based morphometry is used to detect differences in in-vivo Magnetic Resonance Image (MRI) of the mouse brain obtained from two transgenic strains: TASTPM mice that over-express proteins associated with Alzheimer’s disease, and wild-type mice. MRI was carried out at four time points. We compare two different methods to detect group differences in the longitudinal and cross-sectional data. Both methods are based on non-rigid registration of the images to a mouse brain atlas. The whole brain volume measurements on 27 TASTPM and wild-type animals are reproducible to within 0.4% of whole brain volume. The agreement between different methods for measuring volumes in a serial study is shown. The ability to quantify changes in growth between strains in whole brain, hippocampus and cerebral cortex is demonstrated.
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© 2006 Springer-Verlag Berlin Heidelberg
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Maheswaran, S. et al. (2006). Deformation Based Morphometry Analysis of Serial Magnetic Resonance Images of Mouse Brains. In: Pluim, J.P.W., Likar, B., Gerritsen, F.A. (eds) Biomedical Image Registration. WBIR 2006. Lecture Notes in Computer Science, vol 4057. Springer, Berlin, Heidelberg. https://doi.org/10.1007/11784012_8
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DOI: https://doi.org/10.1007/11784012_8
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-35648-6
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