Abstract
Although the voxel-based morphometry (VBM) has been widely used in quantifying the amount of gray matter of the human brain, the optimal amount of registration that should be used in VBM has not been addressed. In this paper, we present a novel multi-scale VBM using the weighted spherical harmonic (SPHARM) representation to address the issue. The weighted-SPHARM provides the explicit smooth functional representation of a true unknown cortical boundary. Based on this new representation, the gray matter tissue density is constructed using the Euclidean distance map from a voxel to the estimated smooth cortical boundary. The methodology is applied in localizing abnormal cortical regions in a group of autistic subjects.
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Ashburner, J., Friston, K.J.: Voxel-Based Morphometry - The Methods. NeuroImage 11, 805–821 (2000)
Bookstein, F.L.: Voxel-based morphometry should not be used with imperfectly registered images. NeuroImage 14, 1454–1462 (2001)
Chung, M.K., Shen, L., Dalton, K.M., Kelley, D.J., Robbins, S.M., Evans, A.C., Davidson, R.J.: Weighted spherical harmonic representation and its application to cortical analysis. Technical Report 1118. Dept. of Stat., University of Wisconsin-Madison, http://www.stat.wisc.edu/~mchung/papers/TR1118.2006.pdf
Davatzikos, C., Genc, A., Xu, D., Resnick, S.M.: Voxel-based morphometry using the RAVENS maps: Methods and validation using simulated longitudinal atrophy. NeuroImage 14, 1361–1369 (2001)
Friedman, J.H., Bentley, J.L., Finkel, R.A.: An algorithm for finding best matches in logarithmic expected Time. ACM transactions on mathematics software 3, 209–226 (1997)
Gerig, G., Styner, M., Jones, D., Weinberger, D., Lieberman, J.: Shape analysis of brain ventricles using spharm. In: MMBIA, pp. 171–178 (2001)
Gu, X., Wang, Y., Chan, T., Thompson, T., Yau, S.T.: Genus zero surface conformal mapping and its application to brain surface mapping. IEEE Transactions on Medical Imaging 23, 1–10 (2004)
MacDonald, J., Kabani, N., Avis, D., Evans, A.: Automated 3-d extraction of inner and outer surfaces of cerebral cortex from MRI. NeuroImage 12, 340–356 (2000)
Paus, T., Zijdenbos, A., Worsley, K., Collins, D.L., Blumenthal, J., Giedd, J.N., Rapoport, J.L., Evans, A.C.: Structural maturation of neural pathways in children and adolescents: In Vivo Study. Science 283, 1908–1911 (1999)
Shen, L., Ford, J., Makedon, F., Saykin, A.: Surface-based approach for classification of 3d neuroanatomical structures. Intelligent Data Analysis 8 (2004)
Thompson, P.M., Hayashi, K.M., de Zubicaray, G., Janke, A.L., Rose, S.E., Semple, J., Herman, D., Hong, M.S., Dittmer, S.S., Doddrell, D.M., Toga, A.W.: Dynamics of gray matter loss in Alzheimer’s disease. Journal of Neuroscience 23, 994–1005 (2003)
Worsley, K.J., Marrett, S., Neelin, P., Vandal, A.C., Friston, K.J., Evans, A.C.: A unified statistical approach for determining significant signals in images of cerebral activation. Human Brain Mapping 4, 58–73 (1996)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Copyright information
© 2006 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Chung, M.K., Shen, L., Dalton, K.M., Davidson, R.J. (2006). Multi-scale Voxel-Based Morphometry Via Weighted Spherical Harmonic Representation. In: Yang, GZ., Jiang, T., Shen, D., Gu, L., Yang, J. (eds) Medical Imaging and Augmented Reality. MIAR 2006. Lecture Notes in Computer Science, vol 4091. Springer, Berlin, Heidelberg. https://doi.org/10.1007/11812715_5
Download citation
DOI: https://doi.org/10.1007/11812715_5
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-37220-2
Online ISBN: 978-3-540-37221-9
eBook Packages: Computer ScienceComputer Science (R0)