Abstract
The availability of increasingly accumulated time-series expression profiles has provided the data structures to study the temporal relationship between genes. The aims of the study were to explore the modes of relationship between the genes periodically expressed in human HeLa cell cycle, and to reversely engineer the dynamic networks of gene transcription. We also studied the phase-specific properties of the genetic relationships by decomposing the whole network into the sub-networks according to the cell cycling phases. The results demonstrated that the gene-gene relationships within a same phase or between different phases followed different modes.
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© 2006 Springer-Verlag Berlin Heidelberg
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Xiao, Y., Li, X., Rao, S., Wang, J., Zhang, Y., Du, L. (2006). An Analysis of Gene Expression Relationships Between Periodically Expressed Genes in the Hela Cells. In: Huang, DS., Li, K., Irwin, G.W. (eds) Computational Intelligence and Bioinformatics. ICIC 2006. Lecture Notes in Computer Science(), vol 4115. Springer, Berlin, Heidelberg. https://doi.org/10.1007/11816102_81
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DOI: https://doi.org/10.1007/11816102_81
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-37277-6
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