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Model Deconstruction of an Immunoprevention Vaccine

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Advances in Natural Computation (ICNC 2006)

Part of the book series: Lecture Notes in Computer Science ((LNTCS,volume 4222))

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Abstract

We present a further step in developing an in silico model that simulates the immune system responses to tumor cells in vaccinated mice. Our study is based on our previous model that simulates the cancer – immune System competition activated by a tumor vaccine. In what follows, we show first results on effects of deconstructing the components of Triplex vaccine that are in very good agreement with in vivo results.

This work was supported in part by IMMUNOGRID project, under EC contract FP6-2004-IST-4, No. 028069. F.P. and S.M. acknowledge partial support from University of Catania research grant and MIUR (PRIN 2004: Problemi matematici delle teorie cinetiche). This work has been done while F.P. is research fellow of the Faculty of Pharmacy of University of Catania. P.-L.L. acknowledges financial support from the University of Bologna, the Department of Experimental Pathology (”Pallotti” fund) and MIUR.

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Author information

Authors and Affiliations

  1. Faculty of Pharmacy, University of Catania,  

    F. Pappalardo

  2. Department of Mathematics and Computer Science, University of Catania,  

    F. Pappalardo, S. Motta & E. Mastriani

  3. Sezione di Cancerologia, Dipartimento di Patologia Sperimentale, and Centro Interdipartimentale di Ricerche sul Cancro ”Giorgio Prodi”, University of Bologna,  

    P. -L. Lollini

Authors
  1. F. Pappalardo
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  2. P. -L. Lollini
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  3. S. Motta
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  4. E. Mastriani
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Editor information

Editors and Affiliations

  1. Life Science Research Center, School of Electronic Engineering, Xidian University, 710071, Xi’an, Shaanxi, China

    Licheng Jiao

  2. School of Electrical and Electronic Engineering, Nanyang Technological University, Block S1, Nanyang Avenue, 639798, Singapore

    Lipo Wang

  3. School of Electronic Engineering, Xidian Univ., P.O. Box, 710071, Xi’an, P.R. China

    Xinbo Gao

  4. College of Mathematics and Information Science, Hebei Normal University, 050016, Shijiazhuang, Hebei, P.R. China

    Jing Liu

  5. Multi-Agent Systems Lab,Department of Computer Science, University of Science and Technology of China, 230026, Hefei, China

    Feng Wu

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© 2006 Springer-Verlag Berlin Heidelberg

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Pappalardo, F., Lollini, P.L., Motta, S., Mastriani, E. (2006). Model Deconstruction of an Immunoprevention Vaccine. In: Jiao, L., Wang, L., Gao, X., Liu, J., Wu, F. (eds) Advances in Natural Computation. ICNC 2006. Lecture Notes in Computer Science, vol 4222. Springer, Berlin, Heidelberg. https://doi.org/10.1007/11881223_43

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  • DOI: https://doi.org/10.1007/11881223_43

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-45907-1

  • Online ISBN: 978-3-540-45909-5

  • eBook Packages: Computer ScienceComputer Science (R0)

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