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Tolerance Dependent on Timing/Amount of Antigen-Dose in an Asymmetric Idiotypic Network

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Knowledge-Based Intelligent Information and Engineering Systems (KES 2006)

Part of the book series: Lecture Notes in Computer Science ((LNAI,volume 4252))

Abstract

Physiological experiments demonstrate establishment of immunological tolerance is controlled by dose-timing and dose-amount of an antigen. My previous study reproduced the tolerance dependent on dose-timing of an antigen in a two Bcell clones network model with an “asymmetric” Bcell-Bcell interaction. This study first clarifies its mechanism using a dynamical system technique:nullcline analysis. Next, this study proposes a three Bcell clones network model with the same style of Bcell-Bcell interaction, and shows the model simulation can reproduce the tolerance dependent on dose-amount of an antigen: high and low zone tolerance. The success of this reproduction is worthy of attention. Because theoretical studies based on the traditional “symmetric” immune network modeling scheme have not been able to reproduce it well. This study would teach us the renewed recognition of “asymmetric” immune network modeling scheme.

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Authors and Affiliations

  1. Tokuyama College of Technology, 3538, Kume, Shunan, Yamaguchi, 745-8585, Japan

    Kouji Harada

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  1. Kouji Harada
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Editor information

Editors and Affiliations

  1. School of Design, Engineering and Computing, Bournemouth University, UK

    Bogdan Gabrys

  2. Centre for SMART Systems, School of Environment and Technology, University of Brighton, BN2 4GJ, Brighton, UK

    Robert J. Howlett

  3. School of Electrical and Information Engineering, Knowledge Based Intelligent Engineering Systems Centre, University of South Australia, SA, 5095, Mawson Lakes, Australia

    Lakhmi C. Jain

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© 2006 Springer-Verlag Berlin Heidelberg

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Harada, K. (2006). Tolerance Dependent on Timing/Amount of Antigen-Dose in an Asymmetric Idiotypic Network. In: Gabrys, B., Howlett, R.J., Jain, L.C. (eds) Knowledge-Based Intelligent Information and Engineering Systems. KES 2006. Lecture Notes in Computer Science(), vol 4252. Springer, Berlin, Heidelberg. https://doi.org/10.1007/11893004_15

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  • DOI: https://doi.org/10.1007/11893004_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-46537-9

  • Online ISBN: 978-3-540-46539-3

  • eBook Packages: Computer ScienceComputer Science (R0)

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