Abstract
This paper examines the influence of the Raf Kinase Inhibitor Protein (RKIP) on the Extracellular signal Regulated Kinase (ERK) signalling pathway [5] through modelling in a Markovian process algebra, PEPA [11]. Two models of the system are presented, a reagent-centric view and a pathway-centric view. The models capture functionality at the level of subpathway, rather than at a molecular level. Each model affords a different perspective of the pathway and analysis. We demonstrate the two models to be formally equivalent using the timing-aware bisimulation defined over PEPA models and discuss the biological significance.
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Calder, M., Gilmore, S., Hillston, J. (2006). Modelling the Influence of RKIP on the ERK Signalling Pathway Using the Stochastic Process Algebra PEPA. In: Priami, C., Ingólfsdóttir, A., Mishra, B., Riis Nielson, H. (eds) Transactions on Computational Systems Biology VII. Lecture Notes in Computer Science(), vol 4230. Springer, Berlin, Heidelberg. https://doi.org/10.1007/11905455_1
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DOI: https://doi.org/10.1007/11905455_1
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