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Modeling Signal Transduction Using P Systems

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Membrane Computing (WMC 2006)

Part of the book series: Lecture Notes in Computer Science ((LNTCS,volume 4361))

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Abstract

Cellular signalling pathways are fundamental to the control and regulation of cell behavior. Understanding of biosignalling network functions is crucial to the study of different diseases and to the design of effective therapies. In this paper we present P systems as a feasible computational modeling tool for cellular signalling pathways that takes into consideration the discrete character of the components of the system and the key role played by membranes in their functioning. We illustrate these cellular models simulating the epidermal growth factor receptor (EGFR) signalling cascade and the FAS–induced apoptosis using a deterministic strategy for the evolution of P systems.

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Author information

Authors and Affiliations

  1. Department of Computer Science/IfM, Louisiana Tech University, P.O. Box 10348, Ruston, LA, 71272, USA

    Andrei Păun

  2. Department of Computer Science and Artificial Intelligence, University of Sevilla, Avda. Reina Mercedes s/n, 41012, Sevilla, Spain

    Mario J. Pérez-Jiménez & Francisco J. Romero-Campero

Authors
  1. Andrei Păun
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  2. Mario J. Pérez-Jiménez
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  3. Francisco J. Romero-Campero
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Editor information

Editors and Affiliations

  1. Leiden Institute of Advanced Computer Science, Universiteit Leiden, Niels Bohrweg 1, 2333, Leiden, CA, The Netherlands

    Hendrik Jan Hoogeboom

  2. Institute of Mathematics of the Romanian Academy, PO Box 1-764, 014700, Bucureşti, Romania

    Gheorghe Păun

  3. Leiden Center of Advanced Computer Science (LIACS), Leiden University, Niels Bohrweg 1, 2333, Leiden, CA, The Netherlands

    Grzegorz Rozenberg

  4. Turku Centre for Computer Science (TUCS), Leminkäisenkatu 14, 20520, Turku, Finland

    Arto Salomaa

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© 2006 Springer-Verlag Berlin Heidelberg

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Păun, A., Pérez-Jiménez, M.J., Romero-Campero, F.J. (2006). Modeling Signal Transduction Using P Systems. In: Hoogeboom, H.J., Păun, G., Rozenberg, G., Salomaa, A. (eds) Membrane Computing. WMC 2006. Lecture Notes in Computer Science, vol 4361. Springer, Berlin, Heidelberg. https://doi.org/10.1007/11963516_7

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  • DOI: https://doi.org/10.1007/11963516_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-69088-7

  • Online ISBN: 978-3-540-69090-0

  • eBook Packages: Computer ScienceComputer Science (R0)

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