Skip to main content

Case-Based Reasoning in the Care of Alzheimer’s Disease Patients

  • Conference paper
  • First Online:
Case-Based Reasoning Research and Development (ICCBR 2001)

Part of the book series: Lecture Notes in Computer Science ((LNAI,volume 2080))

Included in the following conference series:

Abstract

Planning the ongoing care of Alzheimer’s Disease (AD) patients is a complex task, marked by cases that change over time, multiple perspectives, and ethical issues. Geriatric interdisciplinary teams of physicians, nurses and social workers currently plan this care without computer assistance. Although AD is incurable, interventions are planned to improve the quality of life for patients and their families. Much of the reasoning involved is case-based, as clinicians look to case histories to learn which interventions are effective, to document clinical findings, and to train future health care professionals.

There is great variability among AD patients, and within the same patient over time. AD is not yet well enough understood for universally effective treatments to be available. The case-based reasoning (CBR) research paradigm complements the medical research approach of finding treatments effective for all patients by matching patients to treatments that were effective for similar patients in the past.

The Auguste Project is an effort to provide decision support for planning the ongoing care of AD patients, using CBR and other thought processes natural to members of geriatric interdisciplinary teams. System prototypes are used to explore the reasoning processes involved and to provide the forerunners of practical clinical tools. The first system prototype has just been completed. This prototype supports the decision to prescribe neuroleptic drugs to AD patients with behavioral problems. It uses CBR to determine if a neuroleptic drug should be prescribed and rule-based reasoning to select one of five approved neuroleptic drugs for a patient. The first system prototype serves as proof of concept that CBR is useful for planning ongoing care for AD patients. Additional prototypes are planned to explore the research issues raised.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. D. Aha and J. J. Daniels, editors. Case-Based Reasoning Integrations: Papers from the 1998 Workshop, Menlo Park, CA, 1998. AAAI Press.

    Google Scholar 

  2. A. Alzheimer. Über eine eigenartige erkrankung der hirnrinde. In E. Schultze and G. Suell, editors, Allgemeine Zeitschrift für Psychiatrie und Psychisch-Gerichtliche Medizin, volume 64, pages 146–148, Berlin, Germany, 1907. Georg Reimer.

    Google Scholar 

  3. R. Bareiss. Exemplar-Based Knowledge Acquisition: A Unified Approach to Concept Representation, Classification, and Learning. Academic Press, San Diego, CA, 1989.

    MATH  Google Scholar 

  4. B. Bell, R. Bareiss, and R. Beckwith. Sickle cell counselor: A prototype goal-based scenario for instruction in a museum environment. Technical Report 56, The Institute for the Learning Sciences, Evanston, IL, 1994.

    Google Scholar 

  5. R. Bellazi, S. Montani, L. Portinale, and A. Riva. Integrating rule-based and case-based decision making in diabetic patient management. In Althoff K. D., R. Bergmann, and L. K. Branting, editors, Case-Based Reasoning Research and Development: Third International Conference on Case-Based Reasoning, ICCBR-99, pages 386–400, Berlin, 1999. Springer.

    Google Scholar 

  6. J. Berger. Roentgen: Radiation therapy and case-based reasoning. In Proceedings of the Tenth Conference on Artificial Intelligence for Applications, Los Alamitos, CA, 1994. IEEE Computer Society Press.

    Google Scholar 

  7. I. Bichindaritz. MNAOMIA: Improving case-based reasoning for an application in psychiatry. In Artificial Intelligence in Medicine: Applications of Current Technologies, Stanford, CA, 1996. Working Notes of the AAAI-96 Spring Symposium.

    Google Scholar 

  8. I. Bichindaritz, E. Kansu, and K. M. Sullivan. Integrating case-based reasoning, rule-based reasoning and intelligent information retrieval for medical problem solving. In D. Aha and J. J. Daniels, editors, Case-Based Reasoning Integrations: Papers from the 1998 Workshop, pages 22–27, Madison, WI, 1998.

    Google Scholar 

  9. C. Bradburn and J. Zeleznikow. The application of case-based reasoning to the tasks of health care planning. In S. Wess, K. D. Althoff, and M. M. Richter, editors, Topics in Case-Based Reasoning: First European Workshop, EWCBR-93, pages 365–378, Berlin, 1994. Springer-Verlag.

    Google Scholar 

  10. B. Heindl, R. Schmidt, G. Schmidt, M. Haller, P. Pfaller, L. Gierl, and B. Pollwein. A case-based consilarius for therapy recommendation (ICONS): Computer-based advice for calculated antibiotic therapy in intensive care medicine. Computer Methods and Programs in Biomedicine, 52:117–127, 1997.

    Article  Google Scholar 

  11. Alzheimer’s Disease International. World prevalence. London, UK, 2000. http://www.alz.co.uk/alz.

  12. C. E. Kahn and G. M. Anderson. Case-based reasoning and imaging procedure selection. Investigative Radiology, 29:643–647, 1994.

    Article  Google Scholar 

  13. S. Klein, editor. A National Agenda for Geriatric Education: White Papers. US Department of Health and Human Services, Health Resources and Services Administration, Bureau of Health Professions, Rockville, MD, 1995.

    Google Scholar 

  14. P. Koton. Reasoning about evidence in causal explanations. In Proceedings AAAI-88, pages 256–261, San Mateo, CA, 1988. Morgan Kaufmann.

    Google Scholar 

  15. R. T. Macura and K. J Macura. McRad: Radiology image resource with a case-based retrieval system. In M. Veloso and A. Aamodt, editors, Case-Based Reasoning Research and Development: First International Conference, Proceedings ICCBR-95, pages 43–54, Berlin, 1995. Springer-Verlag.

    Chapter  Google Scholar 

  16. C. R. Marling, G. J. Petot, and L. S. Sterling. Integrating case-based and rule-based reasoning to meet multiple design constraints. Computational Intelligence, 15(3):308–332, 1999.

    Article  Google Scholar 

  17. C. R. Marling, P. J. Whitehouse, P. A. Fioritto, and J. E. Bendis. Knowledge sharing and case-based reasoning in geriatric care. In Exploring Synergies of Knowledge Management and Case-Based Reasoning: Papers from the AAAI 1999 Workshop, Menlo Park, CA, 1999. AAAI Press.

    Google Scholar 

  18. K. Maurer, S. Volk, and H. Gerbaldo. Chapter 1: Auguste D. The history of Alois Alzheimer’s first case. In P. J. Whitehouse, K. Maurer, and J. F. Ballenger, editors, Concepts of Alzheimer Disease: Biological, Clinical and Cultural Perspectives, Baltimore, MD, 2000. Johns Hopkins University Press.

    Google Scholar 

  19. B. McLaren and K.D. Ashley. Context sensitive case comparisons in practical ethics: Reasoning about reasons. In Proceedings of the Fifth International Conference on Artificial Intelligence and Law, pages 316–325, New York, NY, 1995. ACM Press.

    Chapter  Google Scholar 

  20. M. R. Mendez, R. J. Martin, K. A. Smyth, and P. J. Whitehouse. Psychiatric symptoms associated with Alzheimer’s disease. Journal of Neuropsychiatry and Clinical Neurosciences, 2:28–33, 1990.

    Google Scholar 

  21. S. Post and P. J. Whitehouse, editors. Genetic Testing for Alzheimer Disease: Ethical and Clinical Issues. Johns Hopkins University Press, Baltimore, MD, 1998.

    Google Scholar 

  22. M. A. Raskind. Psychopharmacology of noncognitive abnormal behaviors in Alzheimer’s disease. Journal of Clinical Psychiatry, 59(9):28–32, 1998.

    Google Scholar 

  23. R. Schmidt, B. Pollwein, and L. Gierl. Case-based reasoning for antibiotics therapy advice. In Althoff K. D., R. Bergmann, and L. K. Branting, editors, Case-Based Reasoning Research and Development: Third International Conference on Case-Based Reasoning, ICCBR-99, pages 550–559, Berlin, 1999. Springer.

    Google Scholar 

  24. L. Teri, R. G. Logsdon, E. Peskind, M. Raskind, M. F. Weiner, R. E. Tractenberg, N. L. Foster, L. S. Schneider, M. Sano, P. Whitehouse, P. Tariot, A. M. Mellow, A. P. Auchus, M. Grundman, R. G. Thomas, K. Schafer, and L. J. Thal. Treatment of agitation in AD: A randomized, placebo-controlled clinical trial. Neurology, 55:1271–1278, 2000.

    Google Scholar 

  25. R. M. Turner. Using schemas for diagnosis. Computer Methods and Programs in Biomedicine, 30:199–208, 1989.

    Article  Google Scholar 

  26. P. J. Whitehouse and D. S. Geldmacher. Pharmacotherapy for Alzheimer’s disease. Clinics in Geriatric Medicine, 10(2):339–350, 1994.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2001 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Marling, C., Whitehouse, P. (2001). Case-Based Reasoning in the Care of Alzheimer’s Disease Patients. In: Aha, D.W., Watson, I. (eds) Case-Based Reasoning Research and Development. ICCBR 2001. Lecture Notes in Computer Science(), vol 2080. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-44593-5_50

Download citation

  • DOI: https://doi.org/10.1007/3-540-44593-5_50

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-42358-4

  • Online ISBN: 978-3-540-44593-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics