Abstract
The standardized visual field assessment, which measures visual function in 76 locations of the central visual area, is an important diagnostic tool in the treatment of the eye disease glaucoma. It helps determine whether the disease is stable or progressing towards blindness, with important implications for treatment. Automatic techniques to classify patients based on this assessment have had limited success, primarily due to the high variability of individual visual field measurements.
The purpose of this paper is to describe the problem of visual field classification to the data mining community, and assess the success of data mining techniques on it. Preliminary results show that machine learning methods rival existing techniques for predicting whether glaucoma is progressing—though we have not yet been able to demonstrate improvements that are statistically significant. It is likely that further improvement is possible, and we encourage others to work on this important practical data mining problem.
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P. Armitage and G. Berry. Statistical Methods in Medical Research. Blackwell Scientific Pulications, Oxford, third edition, 1994.
M.K. Birch, P.K. Wishart, and N.P. O’Donnell. Determining progressive visual field loss in serial humphrey visual fields. Ophthomology, 102(8):1227–1235, 1995.
L. Brigatti, K. Nouri-Mahdavi, M. Weitzman, and J. Caprioli. Automatic detection of glaucomatous visual field progression with neural networks. Archives of Ophthalmol., 115:725–728, 1997.
R.O. Burk, A. Tuulonen, and P.J. Airaksinen. Laser scanning tomography of localised nerve fibre layer defects. British J. of Ophthalmol, 82(10):1112–1117, 1998.
B.C. Chauhan and C.A. Johnson. Test-retest variability of frequency-doubling perimetry and conventional perimetry in glaucoma patients and normal subjects. Investigative Ophthomology and Vision Science, 40(3):648–656, 1999.
B.C. Chauhan, S.M. Drance, and G.R. Douglas. The use of visual field indices in detecting changes in the visual field in glaucoma. Investigative Ophthomology and Vision Science, 31(3):512–520, 1990.
C. Cortes and V. Vapnik. Support vector networks. Machine Learning, 20:273–297, 1995.
D.P. Crabb, F.W. Fitzke, A.I. McNaught, D.F. Edgar, and R.A. Hitchings. Improving the prediction of visual field progression in glaucoma using spatial processing. Ophthomology, 104(3):517–524, 1997.
M. Fingeret and T.L. Lewis. Primary care of the glaucomas. Mc Graw Hill, New York, second edition, 2001.
J.H. Friedman. Greedy function approximation: A gradient boosting machine. Technical report, Department of Statistics, Stanford University, CA, 1999.
D.B. Henson, S.E. Spenceley, and D.R. Bull. Artificial neural network analysis of noisy visual field data in glaucoma. Art. Int. in Medicine, 10:99–113, 1997.
R.C. Holte. Very simple classification rules perform well on most commonly used datasets. Machine Learning, 11:63–91, 1993.
J. Katz. Scoring systems for measuring progression of visual field loss in clinical trials of glaucoma treatment. Ophthomology, 106(2):391–395, 1999.
S. Keerthi, S. Shevade, C. Bhattacharyya, and K. Murthy. Improvements to platt’s SMO algorithm for SVM classifier design. Technical report, Dept. of CSA, Banglore, India, 1999.
J.R. Landis and G.G. Koch. An application of hierarchical kappa-type statistics in the assessment of majority agreement among multiple observers. Biometrics, 33(2):363–374, 1977.
T. Leitman, J. Eng, J. Katz, and H.A. Quigley. Neural networks for visual field analysis: how do they compare with other algorithms. J Glaucoma, 8:77–80, 1999.
M.C. Leske, A. Heijl, L. Hyman, and B. Bengtsson. Early manifest glaucoma trial: design and baseline data. Ophthomology, 106(11):2144–2153, 1999.
S. Mandava, M. Zulauf, T. Zeyen, and J. Caprioli. An evaluation of clusters in the glaucomatous visual field. American J. of Ophthalmol., 116(6):684–691, 1993.
R.K. Morgan, W.J. Feuer, and D.R. Anderson. Statpac 2 glaucoma change probability. Archive of Ophthalmol., 109:1690–1692, 1991.
K. Nouri-Mahdavi, L. Brigatti, M. Weitzman, and J. Caprioli. Comparison of methods to detect visual field progression in glaucoma. Ophthomology, 104(8):1228–1236, 1997.
J. Platt. Fast training of support vector machines using sequential minimal optimization. In Advances in Kernel Methods-Support Vector Learning. MIT Press, Cambridge, MA, 1998.
S.D. Smith, J. Katz, and H.A. Quigly. Analysis of progressive change in automated visual fields in glaucoma. Investigative Ophthomology and Vision Science, 37(7):1419–1428, 1996.
P.G.D. Spry, A.B. Bates, C.A. Johnson, and B.C. Chauhan. Simulation of longitudinal threshold visual field data. Investigative Ophthomology and Vision Science, 41(8):2192–2200, 2000.
J. Weber and H. Ulrich. A perimetric nerve fiber bundle map. International Ophthalmology, 15:193–200, 1991.
C.J. Wild and G.A.F. Weber. Introduction to probability and statistics. Department of Statistics, University of Auckland, New Zealand, 1995.
J.M. Wild, M.K. Hussey, J.G. Flanagan, and G.E. Trope. Pointwise topographical and longitudinal modeling of the visual field in glaucoma. Investigative Ophthomology and Vision Science, 34(6):1907–1916, 1993.
J.M. Wild, N. Hutchings, M.K. Hussey, J.G. Flanagan, and G.E. Trope. Pointwise univariate linear regression of perimetric sensitivity against follow-up time in glaucoma. Ophthomology, 104(5):808–815, 1997.
Ian H. Witten and Eibe Frank. Data Mining: Practical Machine Learning Tools and Techniques with Java Implementations. Morgan Kaufmann, San Francisco, CA, 2000.
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Turpin, A., Frank, E., Hall, M., Witten, I.H., Johnson, C.A. (2001). Determining Progression in Glaucoma Using Visual Fields. In: Cheung, D., Williams, G.J., Li, Q. (eds) Advances in Knowledge Discovery and Data Mining. PAKDD 2001. Lecture Notes in Computer Science(), vol 2035. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-45357-1_17
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DOI: https://doi.org/10.1007/3-540-45357-1_17
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