Abstract
Analytical techniques applied to functional magnetic resonance imaging (fMRI) data require restrictive assumptions about the shape of the blood oxygenation level dependent (BOLD) time series observed at each voxel in response to a stimulation paradigm. In this paper, a radically different and fundamentally pattern recognition-oriented fMRI brain activation mapping approach is proposed. Neural activity is assessed at each voxel on a coupling distance principle between the deterministic alternation sequence of the stimulation paradigm and the sequence of BOLD response nonstationarities detected and characterized by a continuous wavelet transform (CWT). The voxel’s stimulationresponse coupling distance is measured using an adapted version of the string edit distance algorithm. fMRI studies conducted on synthetic and real data demonstrated the superiority of the “coupling distance” brain activation mapping approach over against the Student’s t-test.
Chapter PDF
Similar content being viewed by others
Keywords
- Blood Oxygenation Level Dependent
- Statistical Parametric Mapping
- Continuous Wavelet Transform
- fMRI Signal
- Blood Oxygenation Level Dependent Response
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
References
Bandettini, P.A., Jesmanowicz, A., Wong, E.C., Hyde, J.S.: Processing strategies for time-course data sets in functional MRI of human brain. Magn. Reson. Med., 30 (1993) 161–173
Friston, K.J., Jezzard, P., Turner, R.: Analysis of functional MRI time-series. Human Brain Mapping, 1 (1994) 153–171
Aldroubi, A., Unser M.: Wavelets in Medicine and Biology. CRC Press (1996)
Ruttimann, U.E., Unser, M., Rawlings, R.R., Rio, D., Ramsey, N.F., Mattay, V.S., Hommer, D.W., Frank, J.A., Weinberger, D.R.: Statistical Analysis of Functional MRI Data in the Wavelet Domain. IEEE Trans. Med. Imaging, 17 (1998) 142–154
Wagner, R.A., Fischer, M.J.: The string-to-string correction problem. J. Assoc. Comput. Machinery, 21 (1974) 168–173
Marzal, A., Vidal, E.: Computation of normalized edit distances and applications. IEEE Trans. Pat. Ana. Mach. Int., 15 (1993) 926–932
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2001 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Thoraval, L., Armspach, JP., Namer, I. (2001). Analysis of Brain Functional MRI Time Series Based on Continuous Wavelet Transform and Stimulation-Response Coupling Distance. In: Niessen, W.J., Viergever, M.A. (eds) Medical Image Computing and Computer-Assisted Intervention – MICCAI 2001. MICCAI 2001. Lecture Notes in Computer Science, vol 2208. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-45468-3_105
Download citation
DOI: https://doi.org/10.1007/3-540-45468-3_105
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-42697-4
Online ISBN: 978-3-540-45468-7
eBook Packages: Springer Book Archive