Skip to main content

The Assembly of the Human and Mouse Genomes

  • Conference paper
  • First Online:
Computing and Combinatorics (COCOON 2002)

Part of the book series: Lecture Notes in Computer Science ((LNCS,volume 2387))

Included in the following conference series:

  • 588 Accesses

Abstract

Paired-read shotgun sequencing of a genome consists of randomly sampling segments of a fixed length, say 10,000 base pairs (10Kbp), and directly determining a “read” of 500 to 700bp at the two ends of each segment with an automated DNA sequencing instrument. Reconstructing or “assembling” a very large genome from such a data set was considered impossible at the time Jim Weber and I proposed it for the Human Genome (2.9Gbp) in 1996. Critics claimed that the computation would involve an impossible amount of computer time, that the size and repetitiveness of the genome would confound all attempts at assembly should sufficient computer efficiency be achieved, and that even if an assembly were produced it would be of an extremely poor quality and partial nature.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Myers, G. (2002). The Assembly of the Human and Mouse Genomes. In: Ibarra, O.H., Zhang, L. (eds) Computing and Combinatorics. COCOON 2002. Lecture Notes in Computer Science, vol 2387. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-45655-4_1

Download citation

  • DOI: https://doi.org/10.1007/3-540-45655-4_1

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-43996-7

  • Online ISBN: 978-3-540-45655-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics