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Microvascular Dynamics in the Nailfolds of Scleroderma Patients Studied Using Na-Fluorescein dye

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Information Processing in Medical Imaging (IPMI 2001)

Part of the book series: Lecture Notes in Computer Science ((LNCS,volume 2082))

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Abstract

Dynamic microscopy of the nailfold capillaries using Na- fluorescein dye can be used to assess the condition of the peripheral circulation of Scleroderma patients, yielding more information than simple morphological studies. In this paper we describe a computer based system for this kind of study and present preliminary results on Scleroderma patients. We show how the dye concentrations vary both in time and as a function of distance from the capillary wall in unprecedented resolution, suggesting that a simple permeability model may be applicable to the data.

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References

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Author information

Authors and Affiliations

  1. Imaging Science and Biomedical Engineering, University of Manchester, Manchester, M13 9PT, UK

    Philip D. Allen & Chris J. Taylor

  2. Rheumatic Diseases Centre, Hope Hospital, Salford, M6 8HD, UK

    Ariane L. Herrick, Marina Anderson & Tonia Moore

Authors
  1. Philip D. Allen
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  2. Chris J. Taylor
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  3. Ariane L. Herrick
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  4. Marina Anderson
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  5. Tonia Moore
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Editor information

Editors and Affiliations

  1. Biomedical Engineering, University of California, One Shields Avenue, Davis, CA, 95616, USA

    Michael F. Insana

  2. Signal and Image Processing Institute, University of Southern California, 3740 McClintock Avenue, Los Angeles, CA, 90089-2564, USA

    Richard M. Leahy

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© 2001 Springer-Verlag Berlin Heidelberg

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Allen, P.D., Taylor, C.J., Herrick, A.L., Anderson, M., Moore, T. (2001). Microvascular Dynamics in the Nailfolds of Scleroderma Patients Studied Using Na-Fluorescein dye. In: Insana, M.F., Leahy, R.M. (eds) Information Processing in Medical Imaging. IPMI 2001. Lecture Notes in Computer Science, vol 2082. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-45729-1_21

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  • DOI: https://doi.org/10.1007/3-540-45729-1_21

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-42245-7

  • Online ISBN: 978-3-540-45729-9

  • eBook Packages: Springer Book Archive

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