Abstract
A brief survey of biological research on non-coding DNA is presented here. There has been growing interest in the effects of non-coding segments in evolutionary algorithms (EAs). To better understand and conduct research on non-coding segments and EAs, it is important to understand the biological background of such work. This paper begins with a review of basic genetics and terminology, describes the different types of non-coding DNA, and then surveys recent intron research.
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G. I. Bell and T. G. Marr, editors. Computers and DNA. Addison-Wesley, 1988.
C. C. F. Blake. Do genes-in-pieces imply proteins-in-pieces? Nature, 273:267, 1978.
T. Cavalier-Smith. Intron phylogeny: a new hypothesis. Trends in Genetics, 7(5):145–148, May 1991.
H. Curtis. Biology. Worth Publishers, 1983.
W. F. Doolittle. Genes in pieces: were they ever together? Nature, 272:581, 1978.
W. F. Doolittle. What introns have to tell us: Hierarchy in genome evolution. Cold Spring Harbor Symposia on Quantitative Biology, 52:907–913, 1987.
A. Flavell. Introns continue to amaze. Nature, 316:574–575, August 1985.
S. Forrest and M. Mitchell. Relative building-block fitness and the building-block hypothesis. In FOGA, 1992.
W. Gilbert. Why genes in pieces? Nature, 271:501, February 1978.
W. Gilbert. Genes-in-pieces revisited. Science, 228:823–824, May 1985.
W. Gilbert. The RNA world. Nature, 319:618, February 1986.
W. Gilbert. The exon theory of genes. Cold Spring Harbor Symposia on Quantitative Biology, 52:901–905, 1987.
W. Gilbert. Gene structure and evolutionary theory. In New perspectives on evolution, pages 155–163. Wiley-Liss, 1991.
W. Gilbert and M. Glynias. On the ancient nature of introns. Gene, 135, 1993.
W. Gilbert, M. Marchionni, and G. McKnight. On the antiquity of introns. Cell, 46:151–153, July 1986.
M. Go. Correlation of DNA exonic regions with protein structural units in haemoglobin. Nature, 291:90–92, May 1981.
D. E. Goldberg, B. Korb, and K. Deb. Messy genetic algorithms: Motivation, analysis, and first results. Complex Systems, 3:493–530, 1989.
D. L. Hartl. New perspectives on the molecular evolution of genes and genomes. In New perspectives on evolution, pages 123–137. Wiley-Liss, 1991.
T. Haynes. Duplication of coding segments in genetic programming. In 13th AAAI, 1996.
J. H. Holland. Adaptation in Natural and Artificial Systems. University of Michigan Press, 1975.
J. R. Levenick. Inserting introns improves genetic algorithm success rate: Taking a cue from biology. In ICGA-4, pages 123–127, 1991.
B. Lewin. Genes 5. John Wiley & Sons, 1994.
R. K. Lindsay and A. S. Wu. Testing the robustness of the genetic algorithm on the floating building block representation. In 13th AAAI, 1996.
M. Long, C. Rosenberg, and W. Gilbert. Intron phase correlations and the evolution of the intron/exon structure of genes, 1995. Under review.
M. Marchionni and W. Gilbert. The triosephosphate isomerase gene from maize: introns antedate the plant-animal divergence. Cell, 46:133–141, July 1986.
N. F. McPhee and J. D. Miller. Accurate replication in genetic programming. In ICGA-6, 1995.
M. Nei. Molecular Evolutionary Genetics. Columbia University Press, 1987.
P. Nordin and W. Banzhaf. Complexity compression and evolution. In ICGA-6, 1995.
P. Nordin and W. Banzhaf. Evolving turing-complete programs for a register machine with self modifying code. In ICGA-6, 1995.
P. Nordin, F. Francone, and W. Banzhaf. Explicitly defined introns and destructive crossover in genetic programming. Workshop on GP, ML, 1995.
B. Patrusky. The intron story. MOSAIC, 23(3):22–33, Fall 1992.
M. Robertson. The post-RNA world. Nature, 335:16–18, September 1988.
J. H. Rogers. How were introns inserted into nuclear genes? Trends in Genetics, 5(7):213–216, July 1989.
A. Stoltzfus, D. F. Spencer, M. Zuker, J. M. Logsdon, Jr., and W. F. Doolittle. Testing the exon theory of genes: the evidence from protein structure. Science, 265:202–207, July 1994.
R. A. Wallace, G. Sanders, and R. Ferl. Biology: The Science of Life. Harper College, 3rd edition, 1991.
J. D. Watson. Molecular Biology of the Gene. W. A. Benjamin, 2nd edition, 1970.
A. S. Wu. Non-coding DNA and floating building blocks for the genetic algorithm. PhD thesis, University of Michigan, 1995.
A. S. Wu and R. K. Lindsay. A comparison of the fixed and floating building block representation in the genetic algorithm, 1995. Submitted to Evol. Comp.
A. S. Wu and R. K. Lindsay. Empirical studies of the genetic algorithm with non-coding segments. Evolutionary Computation, 3(2), 1995.
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Wu, A.S., Lindsay, R.K. (1996). A survey of intron research in genetics. In: Voigt, HM., Ebeling, W., Rechenberg, I., Schwefel, HP. (eds) Parallel Problem Solving from Nature — PPSN IV. PPSN 1996. Lecture Notes in Computer Science, vol 1141. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-61723-X_974
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DOI: https://doi.org/10.1007/3-540-61723-X_974
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