Abstract
Parametric imaging procedures offer the possibility of comprehensive assessment of tissue metabolic activity. Estimating variances of these images is important for the development of inference procedures in a diagnostic setting. Unfortunately, the complexity of the radio-tracer models used in the generation of a parametric image makes analytic variance expressions intractable. A natural extension of the usual resampling approach is infeasible because of the computational effort. This paper suggests a computationally practical approximate simulation strategy to variance estimation. Results of experiments done to evaluate the approach in a simplified model one-dimensional problem are very encouraging. The suggested methodology is evaluated here in the context of parametric images extracted by mixture analysis; however, the approach is general enough to extend to other parametric imaging methods.
Research supported in part by the National Institutes of Health grant CA-57903 at the University of Washington, Seattle, USA.
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© 1997 Springer-Verlag Berlin Heidelberg
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Maitra, R. (1997). Synthetic resampling methods for variance estimation in parametric images. In: Duncan, J., Gindi, G. (eds) Information Processing in Medical Imaging. IPMI 1997. Lecture Notes in Computer Science, vol 1230. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-63046-5_21
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DOI: https://doi.org/10.1007/3-540-63046-5_21
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