Abstract
Shape diffeomorphisms are used along with statistical models to localize shape differences within a set of similar surfaces. Diffeomorphisms in images are found by looking at similarities within the intensity function of the image. Surfaces do not enjoy the availability of such an intensity function and one therefore needs to choose which function will give the most accurate match between similar features. Thus, it is important to choose an intensity function that faithfully represents features of the surface as accurately as possible. In this paper, we present a fast method which uses a curvature scale space to capture surface features over a wide range of scales. We recall the relationship between Poisson equation and scale space representations, and we use this relationship to formulate a potential function which integrates curvature information over a wide range of scales. The resulting map is a global function of bending (as measured by curvature) that is used to find diffeomorphic maps between surfaces. The potential function showed to be more accurate than a depth map computed on the surface.
As an application of the depth potential function, we use it to analyze diffeomorphic maps of the human brain through a statistical analysis of surface deformation. We used surfaces extracted from 92 subjects affected with very mild to mild dementia and 97 healthy subjects. Using T 2-statistics on the diffeomorphic map between the groups of demented and non-demented subjects, we were able to detect the atrophy of the interior and exterior temporal lobe due to the presence of mild dementia.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Arsigny, V., Fillard, P., Pennec, X., Ayache, N.: Log-Euclidean metrics for fast and simple calculus on diffusion tensors. Magn. Reson. Med. 56(2), 411–421 (2006)
Boucher, M., Evans, A.: Dealing with uncertainty in the principal directions of tensors. In: Proceedings of the 2008 Conference on Computer Vision and Pattern Recognition Workshop, CVPRW’08, pp. 1–8. IEEE Computer Society, Los Alamitos (2008)
Boucher, M., Evans, A., Siddiqi, K.: Oriented morphometry of folds on surfaces. In: Proceedings of the 21st Conference on Information Processing in Medical Imaging. Lecture Notes in Computer Science, vol. 5636, pp. 614–625. Springer, Berlin (2009)
Boucher, M., Whitesides, S., Evans, A.: Depth potential function for folding pattern representation, registration and analysis. Med. Image Anal. 13(2), 203–214 (2009)
Fischl, B., Sereno, M.I., Dale, A.M.: Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. Neuroimage 9(2), 195–207 (1999)
Florack, L., Duits, R., Bierkens, J.: Tikhonov regularization versus scale space: a new result. In: Proceedings of the 11th International Conference on Image Processing, Singapore, October 24–27, 2004, pp. 271–274. IEEE Press, New York (2004)
Kim, J.S., Singh, V., Lee, J.K., Lerch, J., Ad-Dab’bagh, Y., MacDonald, D., Lee, J.M., Kim, S.I., Evans, A.C.: Automated 3-D extraction and evaluation of the inner and outer cortical surfaces using a Laplacian map and partial volume effect classification. Neuroimage 27(1), 210–221 (2005)
Lepore, N., Brun, C., Chou, Y.Y., Chiang, M.C., Dutton, R.A., Hayashi, K.M., Luders, E., Lopez, O.L., Aizenstein, H.J., Toga, A.W., Becker, J.T., Thompson, P.M.: Generalized tensor-based morphometry of HIV/AIDS using multivariate statistics on deformation tensors. IEEE Trans. Med. Imaging 27(1), 129–141 (2008)
Lyttelton, O., Boucher, M., Robbins, S., Evans, A.C.: An unbiased iterative group registration template for cortical surface analysis. Neuroimage 34(4), 1535–1544 (2007)
MacDonald, D., Kabani, N., Avis, D., Evans, A.C.: Automated 3-D extraction of inner and outer surfaces of cerebral cortex from MRI. NeuroImage 12(3), 340–356 (2000)
Mazziotta, J.C., Toga, A.W., Evans, A., Fox, P., Lancaster, J.: A probabilistic atlas of the human brain: theory and rationale for its development, the International Consortium for Brain Mapping (ICBM). NeuroImage 2(2), 89–101 (1995)
McCullagh, P., Nelder, J., McCullagh, M.C.: Generalized Linear Models. Chapman & Hall/CRC Press, London/Boca Raton (1989)
Meek, C., Patel, J.M., Kasetty, S.: Oasis: an online and accurate technique for local-alignment searches on biological sequences. In: Proceedings of the 29th International Conference on Very Large Data Bases, vol. 29, pp. 910–921. VLDB Endowment, Lyon (2003)
Rettmann, M.E., Han, X., Xu, C., Prince, J.L.: Automated sulcal segmentation using watersheds on the cortical surface. NeuroImage 15(2), 329–344 (2002)
Robbins, S.: Anatomical standardization of the human brain in Euclidean 3-space and on the cortical 2-manifold. PhD thesis, School of Computer Science, McGill University (2004)
Thompson, P.M., Toga, A.W.: A framework for computational anatomy. Comput. Vis. Sci. 5(1), 13–34 (2002)
Thompson, P.M., Hayashi, K.M., De Zubicaray, G., Janke, A.L., Rose, S.E., Semple, J., Herman, D., Hong, M.S., Dittmer, S.S., Doddrell, D.M., et al.: Dynamics of gray matter loss in Alzheimer’s disease. J. Neurosci. 23(3), 994 (2003)
Tosun, D., Rettmann, M.E., Han, X., Tao, X., Xu, C., Resnick, S.M., Pham, D.L., Prince, J.L.: Cortical surface segmentation and mapping. Neuroimage 23(Supplement 1), S108–S118 (2004)
van Essen, D.C.: A population-average, landmark- and surface-based (PALS) atlas of human cerebral cortex. NeuroImage 28(3), 635–662 (2005)
Worsley, K.J.: Local maxima and the expected Euler characteristic of excursion sets of χ 2, f and t fields. Adv. Appl. Probab. 26(1), 13–42 (1994)
Worsley, K.J., Andermann, M., Koulis, T., MacDonald, D., Evans, A.C.: Detecting changes in nonisotropic images. Hum. Brain Mapp. 8(2–3), 98–101 (1999)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer-Verlag London Limited
About this chapter
Cite this chapter
Boucher, M., Evans, A. (2012). Local Statistics on Shape Diffeomorphisms Using a Depth Potential Function. In: Florack, L., Duits, R., Jongbloed, G., van Lieshout, MC., Davies, L. (eds) Mathematical Methods for Signal and Image Analysis and Representation. Computational Imaging and Vision, vol 41. Springer, London. https://doi.org/10.1007/978-1-4471-2353-8_11
Download citation
DOI: https://doi.org/10.1007/978-1-4471-2353-8_11
Published:
Publisher Name: Springer, London
Print ISBN: 978-1-4471-2352-1
Online ISBN: 978-1-4471-2353-8
eBook Packages: Mathematics and StatisticsMathematics and Statistics (R0)