Abstract
Closed-loop control can significantly improve the performance of bioprocesses, e.g., by an increase of the production rate of a target molecule or by guaranteeing reproducibility of the production with low variability. In contrast to the control of chemical reaction systems, the biological reactions take place inside cells which constitute highly regulated, i.e., internally controlled systems by themselves. As a result, through evolution, the same cell can and will mimic a system of first order in some situations and a high-dimensional, highly nonlinear system in others. A complete mathematical description of the possible behaviors of the cell is still beyond reach and would be far too complicated as a basis for model-based process control. This makes supervision, control, and optimization of biosystems very demanding.
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© 2014 Springer-Verlag London
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King, R. (2014). Control of Biotechnological Processes. In: Baillieul, J., Samad, T. (eds) Encyclopedia of Systems and Control. Springer, London. https://doi.org/10.1007/978-1-4471-5102-9_252-1
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DOI: https://doi.org/10.1007/978-1-4471-5102-9_252-1
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Publisher Name: Springer, London
Online ISBN: 978-1-4471-5102-9
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Chapter history
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Latest
Control of Biotechnological Processes- Published:
- 29 April 2020
DOI: https://doi.org/10.1007/978-1-4471-5102-9_252-2
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Original
Control of Biotechnological Processes- Published:
- 06 April 2014
DOI: https://doi.org/10.1007/978-1-4471-5102-9_252-1