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High-Voltage-Activated Calcium Channels

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Encyclopedia of Computational Neuroscience

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Synonyms

Cav1.1–4 “long-lasting” type (L type); Cav2.1 “Purkinje” type (P/Q type); Cav2.2 “non-L type” (N type); Cav2.3 “residual” type (R type); High-voltage-gated calcium channels

Definition

Calcium channels are one of the oldest members of the voltage-gated channel family (Anderson and Greenberg 2001) and are ubiquitous among excitable cells. Calcium channels are composed of a specialized structure, a complex protein placed to bridge the intracellular and extracellular media across the lipidic cell membrane. Under the control of the difference of potential across the cell membrane (membrane voltage or Vm) and biochemical pathways, these channels finely control the flow of calcium (Ca2+) ions into excitable and non-excitable cells. The Ca2+ channels (Cav) are divided into different subfamilies based on their subunits types and assembly, which leads to the creation of channels with different kinetic properties and distinct function in specific sections of the cells.

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References

  • Anderson PA, Greenberg RM (2001) Phylogeny of ion channels: clues to structure and function. Comp Biochem Physiol B Biochem Mol Biol 129(1):17–28

    Article  PubMed  CAS  Google Scholar 

  • Anwar H, Hong S, De Schutter E (2010) Controlling Ca2 + −activated K + channels with models of Ca2+ buffering in Purkinje cells. Cerebellum 11(3):681–693

    Article  PubMed Central  Google Scholar 

  • Arikkath J, Campbell KP (2003) Auxiliary subunits: essential components of the voltage-gated calcium channel complex. Curr Opin Neurobiol 13(3):298–307

    Article  PubMed  CAS  Google Scholar 

  • Buraei Z, Anghelescu M, Elmslie KS (2005) Slowed N-type calcium channel (CaV2.2) deactivation by the cyclin-dependent kinase inhibitor roscovitine. Biophys J 89(3):1681–1691

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Catterall WA (2000) Structure and regulation of voltage-gated Ca2+ channels. Annu Rev Cell Dev Biol 16:521–555

    Article  PubMed  CAS  Google Scholar 

  • D’Angelo E, Nieus T, Maffei A, Armano S, Rossi P, Taglietti V, Fontana A (2001) Theta-frequency bursting and resonance in cerebellar granule cells: experimental evidence and modeling of a slow K + −dependent mechanism. J Neurosci 21(3):759–770

    PubMed  Google Scholar 

  • Diana MA, Otsu Y, Maton G, Collin T, Chat M, Dieudonné S (2007) T-type and L-type Ca2+ conductances define and encode the bimodal firing pattern of vestibulocerebellar unipolar brush cells. J Neurosci Off J Soc Neurosci 27(14):3823–3838

    Article  CAS  Google Scholar 

  • Hille B (2001) Ionic channels of excitable membranes. Sinauer Associates, Sunderland

    Google Scholar 

  • Llinas RR, Sugimori M, Cherksey B (1989) Voltage-dependent calcium conductances in mammalian neurons – the P channel. Ann N Y Acad Sci 560:103–111

    Article  PubMed  CAS  Google Scholar 

  • Mahajan A, Shiferaw Y, Sato D, Baher A, Olcese R, Xie LH, Yang MJ, Chen PS, Restrepo JG, Karma A, Garfinkel A, Qu Z, Weiss JN (2008) A rabbit ventricular action potential model replicating cardiac dynamics at rapid heart rates. Biophys J 94(2):392–410

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Pepke S, Kinzer-Ursem T, Mihalas S, Kennedy MB (2010) A dynamic model of interactions of Ca2+, calmodulin, and catalytic subunits of Ca2+/calmodulin-dependent protein kinase II. PLoS Comput Biol 6(2):e1000675

    Article  PubMed  PubMed Central  Google Scholar 

  • Richards KS, Swensen AM, Lipscombe D, Bommert K (2007) Novel CaV2.1 clone replicates many properties of Purkinje cell CaV2.1 current. Eur J Neurosci 26(10):2950–2961. doi:10.1111/j.1460-9568.2007.05912.x

    Article  PubMed  Google Scholar 

  • Sharman JL, Benson HE, Pawson AJ, Lukito V, Mpamhanga CP, Bombail V, Davenport AP, Peters JA, Spedding M, Harmar AJ, NC-IUPHAR (2013) IUPHAR-DB: updated database content and new features. Nucleic Acids Res 41(Database issue):D1083–D1088

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Tedford HW, Zamponi GW (2006) Direct G protein modulation of Cav2 calcium channels. Pharmacol Rev 58(4):837–862. doi:10.1124/pr.58.4.11.837

    Article  PubMed  CAS  Google Scholar 

  • Tsien RW, Hess P, McCleskey EW, Rosenberg RL (1987) Calcium channels: mechanisms of selectivity, permeation, and block. Annu Rev Biophys Biophys Chem 16:265–290

    Article  PubMed  CAS  Google Scholar 

  • Tsien RW, Lipscombe D, Madison DV, Bley KR, Fox AP (1988) Multiple types of neuronal calcium channels and their selective modulation. TINS 11(10):431–438

    PubMed  CAS  Google Scholar 

  • Umemiya M, Berger AJ (1994) Properties and function of low- and high-voltage-activated Ca2+ channels in hypoglossal motoneurons. J Neurosci Off J Soc Neurosci 14(9):5652–5660

    CAS  Google Scholar 

  • Venugopal S, Hamm TM, Jung R (2012) Differential contributions of somatic and dendritic calcium-dependent potassium currents to the control of motoneuron excitability following spinal cord injury. Cogn eurodynamics 6(3):283–293

    Article  Google Scholar 

  • Wilson SM, Toth PT, Oh SB, Gillard SE, Volsen S, Ren D, Philipson LH et al (2000) The status of voltage-dependent calcium channels in alpha 1E knock-out mice. J Neurosci Off J Soc Neurosci 20(23):8566–8571

    CAS  Google Scholar 

  • Wolf JA, Moyer JT, Lazarewicz MT, Contreras D, Benoit-Marand M, O’Donnell P, Finkel LH (2005) NMDA/AMPA ratio impacts state transitions and entrainment to oscillations in a computational model of the nucleus accumbens medium spiny projection neuron. J Neurosci Off J Soc Neurosci 25(40):9080–9095

    Article  CAS  Google Scholar 

  • Womack MD, Chevez C, Khodakhah K (2004) Calcium-activated potassium channels are selectively coupled to P//Q-type calcium channels in cerebellar Purkinje neurons. J Neurosci 24(40):8818–8822

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Fundation “Neurological Institute IRCCS C. Mondino, Via Mondino 2, I-27100, Pavia, Italy

    Dr. Sergio Solinas & Sathyaa Subramaniyam

  2. Section of Physiologysection, Department of Brain and Behavioral Sciences, University of Pavia, Via Forlanini 6, I-27100, Pavia, Italy

    Stefano Masoli Ph.D. Student

Authors
  1. Dr. Sergio Solinas
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  2. Stefano Masoli Ph.D. Student
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  3. Sathyaa Subramaniyam
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Corresponding author

Correspondence to Sergio Solinas .

Editor information

Editors and Affiliations

  1. Atlanta, Georgia, USA

    Dieter Jaeger

  2. Department of Biomedical Engineering, Florida International University, Miami, Florida, USA

    Ranu Jung

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Solinas, S., Masoli, S., Subramaniyam, S. (2014). High-Voltage-Activated Calcium Channels. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_230-1

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  • DOI: https://doi.org/10.1007/978-1-4614-7320-6_230-1

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  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-7320-6

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