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Modeling Ion Concentrations

Encyclopedia of Computational Neuroscience

Synonyms

Ionic currents; Ionic diffusion; Modeling intracellular ionic concentrations

Definition

Realistic models for ionic concentration changes should capture essential aspects of ionic dynamics which are relevant for neuronal function. Ionic concentration changes affect many ionic channels and thereby also the membrane voltage. In addition, ionic concentration changes (e.g., calcium concentration changes) influence also intracellular biochemical signaling cascades. Ionic dynamics is an important determinant of neuronal inhibition, excitability, and synaptic plasticity. We will first introduce how to model intracellular ionic dynamics in general and then describe briefly some details relevant for modeling calcium and chloride dynamics.

Detailed Description

Ion Influx

Ions enter the neuron via ion channels in the cell membrane. This influx can be modeled as a linear ohmic current:

$$ {I}_{\mathrm{ion}}={g}_{\mathrm{ion}}\ \left(V-{E}_{\mathrm{ion}}\right) $$

where Vis the membrane...

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Author information

Authors and Affiliations

  1. Institute of Clinical Neuroanatomy, Goethe-University Frankfurt, Frankfurt, Germany

    Namrata Mohapatra & Peter Jedlicka

  2. UTSA Neurosciences Institute, University of Texas at San Antonio, San Antonio, TX, USA

    Horace T. Deans & Fidel Santamaria

Authors
  1. Namrata Mohapatra
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  2. Horace T. Deans
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  3. Fidel Santamaria
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  4. Peter Jedlicka
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Corresponding author

Correspondence to Fidel Santamaria .

Editor information

Editors and Affiliations

  1. Atlanta, Georgia, USA

    Dieter Jaeger

  2. Department of Biomedical Engineering, Florida International University, Miami, Florida, USA

    Ranu Jung

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Mohapatra, N., Deans, H.T., Santamaria, F., Jedlicka, P. (2014). Modeling Ion Concentrations. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_239-2

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  • DOI: https://doi.org/10.1007/978-1-4614-7320-6_239-2

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  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-7320-6

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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Chapter history

  1. Latest

    Modeling Ion Concentrations
    Published:
    19 October 2018

    DOI: https://doi.org/10.1007/978-1-4614-7320-6_239-3

  2. Original

    Modeling Ion Concentrations
    Published:
    29 March 2014

    DOI: https://doi.org/10.1007/978-1-4614-7320-6_239-2

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