Definition
The strength of a synapse imparted by a presynaptic neuron onto its postsynaptic target can change as a function of the activity of the presynaptic neuron. This change is referred to as short-term synaptic plasticity. Networks of neurons connected with plastic synapses have the potential ability to display multiple stable solutions either at different parameter values or for the same set of parameters. This latter property is known as multistability. Self-consistency between the network frequency and the level of plasticity is needed to ensure multistability.
Description
The central nervous system (CNS) controls a vast array of behaviors that include both basic functions such as processing of sensory input (Sharp et al. 1990), regulating circadian rhythms (Piggins and Guilding 2011), coordinating motor output (Marder and Calabrese 1996), and more complex functions such as spatial navigation (O’Keefe 1991), decision making, and memory formation (Treves and Rolls 1994)....
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References
Abbott LF, Varela JA, Sen K, Nelson SB (1997) Synaptic depression and cortical gain control. Science 275:220–224
Bose A, Booth V (2011) Co-existent activity patterns in inhibitory neuronal networks with short-term synaptic depression. J Theor Biol 272:42–54
Bose A, Manor Y, Nadim F (2001) Bistable oscillations arising from synaptic depression. SIAM J Appl Math 62:706–727
Carver S, Roth E, Cowan N, Fortune E (2008) Synaptic plasticity can produce and enhance direction selectivity. PLoS Comput Biol 4:e32
Chandrasekaran L, Matveev V, Bose A (2009) Multistability of clustered states in a globally inhibitory network. Physica D Nonlinear Phenom 238:253–263
Cook D, Schwindt P, Grand L, Spain W (2003) Synaptic depression in the localization of sound. Nature 421:66–70
Ermentrout GB, Kopell N (1991) Multiple pulse interactions and averaging in systems of coupled neural oscillators. J Math Biol 29:33–44
Izhikevich E, Desai N, Walcott E, Hoppensteadt F (2003) Bursts as a unit of neural information: selective communication via resonance. Trends Neurosci 26:161–167
Lewis JE, Maler L (2002) Dynamics of electrosensory feedback: short-term plasticity and inhibition in a parallel fiber pathway. J Neurophysiol 88:1695–1706
Manor Y, Nadim F (2001) Synaptic depression mediates bistability in neuronal networks with recurrent inhibitory connectivity. J Neurosci 21:9460–9470
Manor Y, Bose A, Booth V, Nadim F (2003) The contribution of synaptic depression to phase maintenance in a model rhythmic network. J Neurophysiol 90:3513–3528
Marder E, Calabrese R (1996) Principles of rhythmic motor pattern generation. Physiol Rev 76:687–717
O’Keefe J (1991) The hippocampal cognitive map and navigational strategies. In: Paillard J (ed) Brain and space. Oxford University Press, New York, pp 273–295
Piggins H, Guilding C (2011) The neural circadian system of mammals. Essays Biochem 49:1–17
Sharp PE, Muller RU, Kubie JL (1990) Firing properties of hippocampal neurons in a visually-symmetrical stimulus environment: contributions of multiple sensory cues and mnemonic processes. J Neurosci 10:3093–3105
Tabak J, Senn W, O’Donovan M, Rinzel J (2000) Modeling of spontaneous activity in developing spinal cord using activity-dependent depression in an excitatory network. J Neurosci 20:3041–3056
Thomson AM (2000) Molecular frequency filters at central synapses. Prog Neurobiol 62:159–196
Treves A, Rolls ET (1994) A computational analysis of the role of the hippocampus in memory. Hippocampus 4:373–391
Tsodyks M, Markram H (1997) The neural code between neocortical pyramidal neurons depends on the transmitter release probability. Proc Natl Acad Sci U S A 94:719–723
Tsodyks M, Uziel A, Markram H (2000) Synchrony generation in recurrent networks with frequency-dependent synapses. J Neurosci 20(1–5):RC50
Acknowledgments
This work was supported in part by NSF DMS 1122291 (AB, FN) and NIH MH-60605 (FN).
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Bose, A., Nadim, F. (2014). Multistability Arising from Synaptic Dynamics. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_272-1
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DOI: https://doi.org/10.1007/978-1-4614-7320-6_272-1
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