Definition
Several types of seizures manifest themselves in stereotyped patterns of electrical activity characterized by large-amplitude periodic fluctuations of the local field potential (LFP), alternations of the spike/polyspike and wave (SW/PSW) EEG discharges, and fast runs of EEG spikes. Alternations between different types of activity over the course of a seizure may be explained by transitions between different states of the multistable dynamical system describing the brain network in the pathological epileptic condition. Furthermore, the epileptic state itself may represent one of many dynamical states, including a healthy state, which coexist in the same brain network. Thus, understanding the role of multistability is of tremendous importance for identifying the mechanisms and driving factors of epileptic seizures.
Detailed Description
Many types of epileptic seizures, including absence seizures, Lennox-Gastaut syndrome, West syndrome, and posttraumatic epilepsy (Niedermeyer 2005...
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Supported by grant 1 R01 NS059740 and 5 R01 NS060870.
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Bazhenov, M., Krishnan, G.P. (2014). Multistability in Seizure Dynamics. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_302-1
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DOI: https://doi.org/10.1007/978-1-4614-7320-6_302-1
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