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Morphologically Detailed Motoneuron Models

Encyclopedia of Computational Neuroscience
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Definition

Morphologically detailed motoneuron models refer to a class of motoneuron (MN) models that are developed using experimentally-derived three-dimensional digital reconstructions of MN anatomy (Fig. 1, left panel). In contrast to models with reduced morphological detail (Fig. 1, right panel), morphologically detailed models offer more accurate spatial resolution and allow realistic distribution of electrical properties.

Fig. 1
figure 1

A morphologically detailed model (left) versus its reduced counterpart for the same MN (cell 43c5 originally published in Cullheim et al. 1987)

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References

  • Amendola J, Durand J (2008) Morphological differences between wild-type and transgenic superoxide dismutase 1 lumbar motoneurons in postnatal mice. J Comp Neurol 511:329–341

    Article  PubMed  Google Scholar 

  • Clements JD, Redman SJ (1989) Cable properties of cat spinal motoneurones measured by combining voltage clamp, current clamp and intracellular staining. J Physiol 409:63–87

    CAS  PubMed Central  PubMed  Google Scholar 

  • Cullheim S, Fleshman JW, Glenn LL, Burke RE (1987) Membrane area and dendritic structure in type-identified triceps surae alpha motoneurons. J Comp Neurol 255:68–81

    Article  CAS  PubMed  Google Scholar 

  • Elbasiouny SM, Bennett DJ, Mushahwar VK (2005) Simulation of Dendritic Cav1.3 channels in cat lumbar motoneurons: spatial distribution. J Neurophysiol 94:3961–3974

    Article  CAS  PubMed  Google Scholar 

  • Fleshman J, Segev I, Burke R (1988) Electrotonic architecture of type-identified alpha-motoneurons in the cat spinal cord. J Neurophysiol 60:60–85

    CAS  PubMed  Google Scholar 

  • Hendrickson EB, Edgerton JR, Jaeger D (2011) The capabilities and limitations of conductance-based compartmental neuron models with reduced branched or unbranched morphologies and active dendrites. J Comput Neurosci 30:301–321

    Article  PubMed Central  PubMed  Google Scholar 

  • Holmes WR, Rall W (1992) Estimating the electrotonic structure of neurons with compartmental models. J Neurophysiol 68:1438–1452

    CAS  PubMed  Google Scholar 

  • Holmes WR, Segev I, Rall W (1992) Interpretation of time constant and electrotonic length estimates in multicylinder or branched neuronal structures. J Neurophysiol 68:1401–1420

    CAS  PubMed  Google Scholar 

  • Jackson ME, Cauller LJ (1997) Evaluation of simplified compartmental models of reconstructed neocortical neurons for use in large-scale simulations of biological neural networks. Brain Res Bull 44:7–17

    Article  CAS  PubMed  Google Scholar 

  • Kitzman P (2005) Alteration in axial motoneuronal morphology in the spinal cord injured spastic rat. Exp Neurol 192:100–108

    Article  PubMed  Google Scholar 

  • Rall W (1962) Theory of physiological properties of dendrites. Ann N Y Acad Sci 96:1071–1092

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Sherif M. Elbasiouny .

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Elbasiouny, S.M. (2014). Morphologically Detailed Motoneuron Models. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_371-1

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  • DOI: https://doi.org/10.1007/978-1-4614-7320-6_371-1

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Chapter history

  1. Latest

    Morphologically Detailed Cellular and Pool Motoneuron Models
    Published:
    20 May 2020

    DOI: https://doi.org/10.1007/978-1-4614-7320-6_371-2

  2. Original

    Morphologically Detailed Motoneuron Models
    Published:
    28 March 2014

    DOI: https://doi.org/10.1007/978-1-4614-7320-6_371-1