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Multi-scale Modeling of Purkinje Cells

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Encyclopedia of Computational Neuroscience

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Definition

The Purkinje cell is one of the most extensively modeled neurons in computational neuroscience. Purkinje cells have large dendritic trees that contain more than 150,000 dendritic spines. While dendritic spines are femto-liter cytosolic volumes with lengths of less than 2 μm, the dendritic tree can have a total length of hundreds of microns and thousands of femto-liters in volume. Thus, biochemical and electrical interactions take place over three orders of magnitude in space. Similarly, the time constant of activation of the different dendritic and somatic active conductances ranges from sub-milliseconds to almost 1 s (four orders of magnitude). Therefore, a comprehensive computational study of the Purkinje cell has to be done using multi-scale models and modeling techniques.

Detailed Description

Models of Purkinje cells range from perceptrons to detailed biochemical models of single synapses to biophysical models that take into account the intricate dendritic structure.

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Author information

Authors and Affiliations

  1. Department of Biology, The University of Texas at San Antonio, San Antonio, TX, 78249, USA

    Fidel Santamaria & Emmanuel A. Michaelides

Authors
  1. Fidel Santamaria
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  2. Emmanuel A. Michaelides
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Corresponding author

Correspondence to Fidel Santamaria .

Editor information

Editors and Affiliations

  1. Atlanta, Georgia, USA

    Dieter Jaeger

  2. Department of Biomedical Engineering, Florida International University, Miami, Florida, USA

    Ranu Jung

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Santamaria, F., Michaelides, E.A. (2014). Multi-scale Modeling of Purkinje Cells. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_473-2

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  • DOI: https://doi.org/10.1007/978-1-4614-7320-6_473-2

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  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-7320-6

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