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Hippocampus, Model Network Architecture

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Encyclopedia of Computational Neuroscience

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Definition

Hippocampus, Model Network Architecture refers to the mathematical models used to describe cell connectivity and activity in computational models of the hippocampus. Models of the hippocampus contain two main components: (1) the structure of connections between the cells/regions and (2) the cell types used as the building blocks of the model.

Detailed Description

Basic Hippocampal Anatomy

The hippocampus proper is composed of three subregions: CA1, CA2, and CA3. However, many models actually represent the hippocampal formation, which additionally includes the dentate gyrus (DG), subiculum (SUB), presubiculum, parasubiculum, and entorhinal cortex (EC) (Amaral and Lavenex 2006). Many hippocampal models focus on the representation of a single subregion or the interactions between regions. One aspect of the hippocampus that differentiates it from other cortical regions is that connections between subregions tend to be unidirectional, creating loops of which have important...

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Further Reading

  • Connectivity

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  • Witter MP (2010) Connectivity of the hippocampus. In: Cutsuridis V, Graham B, Cobb S, Vida I (eds) Hippocampal microcircuits: a computational modeler’s resource book. Springer, New York, pp 5–26

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  • Cell Types

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  • Migliore M, Ascoli GA, Jaffe DB (2010) CA3 Cells: detailed and simplified pyramidal cell models. In: Cutsuridis V, Graham B, Cobb S, Vida I (eds) Hippocampal microcircuits: a computational modeler’s resource book. Springer, New York, pp 399–422

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  • Poirazi P, Pissadaki E-K (2010) The making of a detailed CA1 pyramidal neuron model. In: Cutsuridis V, Graham B, Cobb S, Vida I (eds) Hippocampal microcircuits: a computational modeler’s resource book. Springer, New York, pp 317–352

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  • Skinner F, Saraga F (2010) Single neuron models: interneurons. In: Cutsuridis V, Graham B, Cobb S, Vida I (eds) Hippocampal microcircuits: a computational modeler’s resource book. Springer, New York, pp 399–422

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Author information

Authors and Affiliations

  1. Department of Bioengineering, University of Pennsylvania, 210 S. 33rd Street 240 Skirkanich Hall, 19104-6321, PA, Philadelphia

    Sarah Feldt Muldoon Ph.D.

Authors
  1. Sarah Feldt Muldoon Ph.D.
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Corresponding author

Correspondence to Sarah Feldt Muldoon Ph.D. .

Editor information

Editors and Affiliations

  1. Atlanta, Georgia, USA

    Dieter Jaeger

  2. Department of Biomedical Engineering, Florida International University, Miami, Florida, USA

    Ranu Jung

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Feldt Muldoon, S. (2013). Hippocampus, Model Network Architecture. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_476-1

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  • DOI: https://doi.org/10.1007/978-1-4614-7320-6_476-1

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  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-7320-6

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