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The Cell Centered Database (CCDB; http://ccdb.ucsd.edu) project was launched in 2002 to provide online repository of high-resolution 3D light and electron microscopic reconstructions of cells and subcellular structures (Martone et al. 2002, 2003, 2008). The CCDB was designed to complement the structural databases of gene, protein, and tissue structure by hosting data in the dimensional range known as the “mesoscale,” roughly encompassing the structures that sit between gross morphology and molecular structure, e.g., cellular networks, cellular and subcellular microdomains along with their macromolecular constituents. The study of mesoscale structures continues to present a challenge to experimentalists, because to build a comprehensive understanding of complex tissues in this dimensional range requires the ability to aggregate data obtained by multiple researchers across techniques and spatial scales.
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The types of imaging data stored in the...
References
Martone ME, Gupta A, Wong M, Qian X, Sosinsky G, Ludaescher B, Ellisman MH (2002) A cell centered database for electron tomographic data. J Struct Biol 138:145–155
Martone ME, Zhang S, Gupta A, Qian X, He H, Price DL, Wong M, Santini S, Ellisman MH (2003) The cell-centered database: a database for multiscale structural and protein localization data from light and electron microscopy. Neuroinformatics 1(4):379–395
Martone ME, Tran J, Wong WW, Sargis J, Fong L, Larson S, Lamont SP, Gupta A, Ellisman MH (2008) The cell centered database project: an update on building community resources for managing and sharing 3D imaging data. J Struct Biol 161(3):220–231, Epub 16 Oct 2007, PMID: 18054501
Orloff DN1, Iwasa JH, Martone ME, Ellisman MH, Kane CM.The cell: an image library-CCDB: a curated repository of microscopy data. Nucleic Acids Res. 2013 Jan;41(Database issue):D1241-50. doi: 10.1093/nar/gks1257. Epub 29 Nov 2012
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Martone, M. (2014). Cell Centered Database. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_487-1
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DOI: https://doi.org/10.1007/978-1-4614-7320-6_487-1
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