Skip to main content

Spontaneous Activity, Models of

  • Living reference work entry
  • First Online:
Encyclopedia of Computational Neuroscience
  • 220 Accesses

Synonyms

Models of ongoing activity; Models of resting-state activity

Definition

Whole-brain computational models of the spontaneous dynamics of coupled brain areas. These models are useful to investigate the origin of ongoing fluctuations observed in brain activity during rest and their correlation structure.

Detailed Description

A growing body of neuroimaging research has revealed that during rest the brain exhibits spontaneous fluctuations in neural activity. These fluctuations emerge spontaneously during quiet wakeful rest and vanish either when triggered by a task or when falling asleep. This type of spontaneous activity has been mostly detected in the blood-oxygen level-dependent (BOLD) signal using functional magnetic resonance imaging (fMRI) (Biswal et al. 1995). Explorations into the spatial organization of these spontaneous activations have revealed the existence of correlated activity (or functional connectivity) between spatially segregated brain areas. These functional...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

References

  • Biswal B, Yetkin FZ, Haughton VM, Hyde JS (1995) Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Soc Magn Reson Med 34(4):537–541

    Article  CAS  Google Scholar 

  • Cabral J, Hugues E, Sporns O, Deco G (2011) Role of local network oscillations in resting-state functional connectivity. Neuroimage 57:130–139

    Article  PubMed  Google Scholar 

  • Cabral J, Hugues E, Kringelbach ML, Deco G (2012) Modeling the outcome of structural disconnection on resting-state functional connectivity. Neuroimage 62:1342–1353

    Article  PubMed  Google Scholar 

  • Cabral J, Kringelbach ML, Deco G (2014) Exploring the network dynamics underlying brain activity during rest. Progress in Neurobiology 114:102–131

    Google Scholar 

  • Deco G, Jirsa VK (2012) Ongoing cortical activity at rest: criticality, multistability, and ghost attractors. J Neurosci 32:3366–3375

    Article  CAS  PubMed  Google Scholar 

  • Deco G, Jirsa VK, McIntosh AR, Sporns O, Kötter R (2009) Key role of coupling, delay, and noise in resting brain fluctuations. Proc Natl Acad Sci U S A 106:10302–10307

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Deco G, Jirsa VK, McIntosh AR (2013a) Resting brains never rest: computational insights into potential cognitive architectures. Trends Neurosci 36:268–274

    Article  CAS  PubMed  Google Scholar 

  • Deco G, Ponce-Alvarez A, Mantini D, Romani GL, Hagmann P, Corbetta M (2013b) Resting-state functional connectivity emerges from structurally and dynamically shaped slow linear fluctuations. J Neurosci 33(27):11239–11252

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Friston KJ, Harrison L, Penny W (2003) Dynamic causal modelling. Neuroimage 19:1273–1302

    Article  CAS  PubMed  Google Scholar 

  • Ghosh A, Rho Y, McIntosh AR, Kotter R, Jirsa VK (2008) Cortical network dynamics with time delays reveals functional connectivity in the resting brain. Cogn Neurodyn 2:115–120

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Hagmann P, Cammoun L, Gigandet X, Meuli R, Honey CJ, Wedeen VJ, Sporns O (2008) Mapping the structural core of human cerebral cortex. PLoS Biol 6:e159

    Article  PubMed Central  PubMed  Google Scholar 

  • Honey CJ, Kötter R, Breakspear M, Sporns O (2007) Network structure of cerebral cortex shapes functional connectivity on multiple time scales. Proc Natl Acad Sci U S A 104:10240–10245

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Honey CJ, Sporns O, Cammoun L, Gigandet X, Thiran JP, Meuli R, Hagmann P (2009) Predicting human resting-state functional connectivity from structural connectivity. Proc Natl Acad Sci U S A 106:2035–2040

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Kötter R (2004) Online retrieval, processing, and visualization of primate connectivity data from the CoCoMac database. Neuroinformatics 2:127–144

    Article  PubMed  Google Scholar 

  • Ritter P, Schirner M, McIntosh AR, Jirsa VK (2013) The virtual brain integrates computational modeling and multimodal neuroimaging. Brain Connect 3:121–145

    Article  PubMed Central  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Joana Cabral .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer Science+Business Media New York

About this entry

Cite this entry

Cabral, J., Deco, G. (2014). Spontaneous Activity, Models of. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_584-1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-7320-6_584-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-7320-6

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

Publish with us

Policies and ethics