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Spinal Stimulation for Parkinson Treatment

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Encyclopedia of Computational Neuroscience

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Synonyms

Dorsal column stimulation; Epidural stimulation; Spinal cord stimulation

Definition

Spinal stimulation for Parkinson treatment is a neuromodulation procedure proposed as therapy for alleviating the motor symptoms of Parkinson’s disease. It requires the epidural implant of bipolar electrodes in the dorsal portion of the spinal cord to deliver electrical pulses at specific frequencies.

Detailed Description

Spinal cord stimulation is a technique used for treating chronic pain conditions which are refractory to pharmacological therapies. In 2009 it was proposed that spinal cord stimulation could be used for treating the motor symptoms of Parkinson’s disease (PD). PD is characterized by a lack of dopamine due to the death of the dopaminergic neurons of the substantia nigra. It interferes with the normal functioning of the corticobasal ganglia causing the classical symptoms of hypokinesia and rigidity, that is, slow movements and stiffness of the joints.

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Further Reading

  • Agari T, Date I (2012) Spinal cord stimulation for the treatment of abnormal posture and gait disorder in patients with Parkinson’s disease. Neurol Med Chir 52:470–474

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  • Fénelon G, Goujon C, Gurruchaga J-M, Cesaro P, Jarraya B, Palfi S, Lefaucheur J-P (2011) Spinal cord stimulation for chronic pain improved motor function in a patient with Parkinson’s disease. Parkinsonism Relat Disord 18:1–2

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  • Fuentes R, Petersson P, Siesser WB, Caron MG, Nicolelis MAL (2009) Spinal cord stimulation restores locomotion in animal models of Parkinson’s disease. Science 323(5921):1578–1582

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  • Fuentes R, Petersson P, Nicolelis MAL (2010) Restoration of locomotive function in Parkinson’s disease by spinal cord stimulation: mechanistic approach. Eur J Neurosci 32(7):1100–1108

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  • Hassan S, Amer S, Alwaki AR, Elborno A (2013) A patient with Parkinson’s disease benefits from spinal cord stimulation. J Clin Neurosci 20:1155–1156

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  • Landi A, Trezza A, Pirillo D, Vimercati A, Antonini A, Sganzerla EP (2012) Spinal cord stimulation for the treatment of sensory symptoms in advanced Parkinson’s disease. Neuromodul J Int Neuromodul Soc 2012:276–279

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  • Thevathasan W, Mazzone P, Jha A, Djamshidian A, Dileone M, Di Lazzaro V, Brown P (2010) Spinal cord stimulation failed to relieve akinesia or restore locomotion in Parkinson disease. Neurology 74(16):1325–1327

    Article  CAS  PubMed Central  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Edmond and Lily Safra International Neuroscience Institute, Natal, Brazil

    Romulo Fuentes

Authors
  1. Romulo Fuentes
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Corresponding author

Correspondence to Romulo Fuentes .

Editor information

Editors and Affiliations

  1. Atlanta, Georgia, USA

    Dieter Jaeger

  2. Department of Biomedical Engineering, Florida International University, Miami, Florida, USA

    Ranu Jung

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© 2014 Springer Science+Business Media New York

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Fuentes, R. (2014). Spinal Stimulation for Parkinson Treatment. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_600-4

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  • DOI: https://doi.org/10.1007/978-1-4614-7320-6_600-4

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  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-7320-6

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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