Definition
Ion channels are both the primary cause of excitability disorders (e.g., epilepsy; myotonia; cardiac arrhythmia) and the principle target of many pharmaceutical compounds. Because ion channels both respond to and regulate the cellular response to stimuli, they are the dominant molecules governing excitability of neurons and networks. Computational models of drug effects and genetic mutations reveal the mechanisms underlying channel function, allowing prediction to be validated in silico and generating new hypotheses that can be tested via biological experimentation.
Detailed Description
Ion channels containing an intrinsic ion permeable path can be broadly divided into two main functional categories, based on the mechanism by which they undergo the changes in protein conformation that opens or closes the ion permeation pathway (Sharman et al. 2013), allowing ions to flow down their...
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Klassen, T., Chen, T.T. (2013). Neuropharmacological Modeling, Pharmacogenomics and Ion Channel Modulation. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_715-1
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DOI: https://doi.org/10.1007/978-1-4614-7320-6_715-1
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Publisher Name: Springer, New York, NY
Online ISBN: 978-1-4614-7320-6
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