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Pathological Changes in Peripheral Nerve Excitability

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Encyclopedia of Computational Neuroscience

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Definition

Reversing pathological changes in nerve excitability is an important clinical goal. Achieving that goal requires identification of the underlying molecular changes and a clear understanding of how excitability is altered on the basis of those changes. Computational modeling plays an important role in addressing those issues. One approach involves incorporating known or suspected ion channel changes into normal axon models to test whether such changes can explain pathological changes in excitability. An alternative approach involves reproducing the pathological changes in excitability and then working backward to identify which ion channel changes may be involved.

Detailed Description

Nerve Injury: From Clinical Symptoms to Molecular Pathology

Peripheral nerves comprise axons of sensory, motor, and autonomic neurons. The signs and symptoms of nerve injury reflect which of those axons are damaged. The most obvious consequence of nerve injury is a loss of normal function which,...

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Author information

Authors and Affiliations

  1. Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Canada

    Dr. Steven A. Prescott

  2. Department of Physiology, University of Toronto, Toronto, Canada

    Dr. Steven A. Prescott

Authors
  1. Dr. Steven A. Prescott
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Correspondence to Steven A. Prescott .

Editor information

Editors and Affiliations

  1. Atlanta, Georgia, USA

    Dieter Jaeger

  2. Department of Biomedical Engineering, Florida International University, Miami, Florida, USA

    Ranu Jung

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© 2014 Springer Science+Business Media New York

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Prescott, S.A. (2014). Pathological Changes in Peripheral Nerve Excitability. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_748-1

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  • DOI: https://doi.org/10.1007/978-1-4614-7320-6_748-1

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  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-7320-6

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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