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Cerebellum: Overview

Encyclopedia of Computational Neuroscience

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Definition

The cerebellum processes sensory and motor information. Structurally is divided in the cerebellar cortex network and the deep cerebellar nuclei. Inputs to the cerebellar cortex arrive via the mossy fibers from multiple sources; mossy fibers contact granule cells, Golgi cells and unipolar brush cells. The second input to the cerebellar cortex comes from the inferior olive in the form of climbing fibers that synapse Purkinje cells. The output of the cerebellar cortex is provided by Purkinje cells that integrate the synaptic activity of climbing fibers, granule cells, and inhibitory interneurons. Golgi cells provide an inhibitory feedback mechanism to the granule cell layer. The deep cerebellar nuclei are the final integrator of cerebellar information. Cells in the deep cerebellar nuclei receive input from Purkinje cells, mossy fibers and climbing fibers.

Detailed Description

Cerebellar Cortex

The widely studied cerebellar cortex is composed, mainly, of four types of neurons:...

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References

  • Braitenberg V, Atwood RP (1958) Morphological observations on the cerebellar cortex. J Comp Neurol 109:1–33

    Article  CAS  PubMed  Google Scholar 

  • Clopath C, Nadal JP, Brunel N (2012) Storage of correlated patterns in standard and bistable Purkinje cell models. PLoS Comput Biol 8:e1002448

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • De Schutter E, Bower JM (1994) An active membrane model of the cerebellar Purkinje cell. I. Simulation of current clamps in slice. J Neurophysiol 71:375–400

    PubMed  Google Scholar 

  • Doi T, Kuroda S, Michikawa T, Kawato M (2005) Inositol 1,4,5-trisphosphate-dependent Ca2+ threshold dynamics detect spike timing in cerebellar Purkinje cells. J Neurosci 25:950–961

    Article  CAS  PubMed  Google Scholar 

  • Feil R, Hartmann J, Luo C, Wolfsgruber W, Schilling K, Feil S, Barski JJ, Meyer M, Konnerth A, De Zeeuw CI, Hofmann F (2003) Impairment of LTD and cerebellar learning by Purkinje cell-specific ablation of cGMP-dependent protein kinase I. J Cell Biol 163:295–302

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Gauck V, Jaeger D (2000) The control of rate and timing of spikes in the deep cerebellar nuclei by inhibition. J Neurosci 20:3006–3016

    CAS  PubMed  Google Scholar 

  • Ito M (2006) Cerebellar circuitry as a neuronal machine. Prog Neurobiol 78:272–303

    Article  PubMed  Google Scholar 

  • Lainé J, Axelrad H (1996) Morphology of the Golgi-impregnated lugaro cell in the rat cerebellar cortex: a reappraisal with a description of its axon. J Comp Neurol 375:618–640

    Article  PubMed  Google Scholar 

  • Mugnaini E, Floris A (1994) The unipolar brush cell: a neglected neuron of the mammalian cerebellar cortex. J Comp Neurol 339:174–180

    Article  CAS  PubMed  Google Scholar 

  • Santamaria F, Tripp PG, Bower JM (2007) Feedforward inhibition controls the spread of granule cell-induced Purkinje cell activity in the cerebellar cortex. J Neurophysiol 97:248–263

    Article  PubMed  Google Scholar 

  • Steuber V, Mittmann W, Hoebeek FE, Silver RA, De Zeeuw CI, Häusser M, De Schutter E (2007) Cerebellar LTD and pattern recognition by Purkinje cells. Neuron 54:121–136

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Tanaka K, Khiroug L, Santamaria F, Doi T, Ogasawara H, Ellis-Davies GC, Kawato M, Augustine GJ (2007) Ca2+ requirements for cerebellar long-term synaptic depression: role for a postsynaptic leaky integrator. Neuron 54:787–800

    Article  CAS  PubMed  Google Scholar 

  • Xia J, Chung HJ, Wihler C, Huganir RL, Linden DJ (2000) Cerebellar long-term depression requires PKC-regulated interactions between GluR2/3 and PDZ domain-containing proteins. Neuron 28:499–510

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Biology, University of Texas at San Antonio, San Antonio, TX, USA

    Fidel Santamaria

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  1. Fidel Santamaria
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Correspondence to Fidel Santamaria .

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Editors and Affiliations

  1. Atlanta, Georgia, USA

    Dieter Jaeger

  2. Department of Biomedical Engineering, Florida International University, Miami, Florida, USA

    Ranu Jung

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Santamaria, F. (2014). Cerebellum: Overview. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_779-3

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  • DOI: https://doi.org/10.1007/978-1-4614-7320-6_779-3

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  • Online ISBN: 978-1-4614-7320-6

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Chapter history

  1. Latest

    Cerebellum: Overview
    Published:
    28 March 2014

    DOI: https://doi.org/10.1007/978-1-4614-7320-6_779-2

  2. Original

    Cerebellum: Overview
    Published:
    28 March 2014

    DOI: https://doi.org/10.1007/978-1-4614-7320-6_779-3

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