Abstract
Protein-protein interaction networks provide important clues about cell function. However, the picture offered by protein interaction alone is incomplete, because techniques for determining interactions at genome scale lack details as to how they are mediated. Stable protein interactions are thought to be largely mediated by interactions between protein domains while transient interactions occur often between small globular domains and short protein peptides, the so called linear motifs. Recently a number of computational methods to predict interactions between two domains and between a domain and a (possibly modified) peptide have been proposed. In this chapter we review representative computational methods focusing on those that use high throughput protein interaction networks to uncover domain-domain and domain-peptide interactions.
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Guimarães, K.S., Przytycka, T.M. (2008). Protein Interaction Network Based Prediction of Domain-Domain and Domain-Peptide Interactions. In: Panchenko, A., Przytycka, T. (eds) Protein-protein Interactions and Networks. Computational Biology, vol 9. Springer, London. https://doi.org/10.1007/978-1-84800-125-1_5
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DOI: https://doi.org/10.1007/978-1-84800-125-1_5
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