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Deep Learning Based Temporal Information Extraction Framework on Chinese Electronic Health Records

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Web Information Systems and Applications (WISA 2018)

Part of the book series: Lecture Notes in Computer Science ((LNISA,volume 11242))

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Abstract

Electronic Health Records (EHRs) are generated in the clinical treatment process and contain a large number of medical knowledge, which is closely related to the health status of patients. Thus information extraction on unstructured clinical notes in EHRs is important which could contribute to huge improvement in patient health management. Besides, temporal related information extraction seems to be more essential since clinical notes are designed to capture states of patients over time. Previous studies mainly focused on English corpus. However, there are very limited research work on Chinese EHRs. Due to the challenges brought by the characteristics of Chinese, it is difficult to apply existing techniques for English on Chinese corpus directly. Considering this situation, we proposed a deep learning based temporal information extraction framework in this paper. Our framework contains three components: data preprocessing, temporal entity extraction and temporal relation extraction. For temporal entity extraction, we proposed a recurrent neural network based model, using bidirectional long short-term memory (LSTM) with Conditional Random Fields decoding (LSTM-CRF). For temporal relation extraction, we utilize Convolutional Neural Network (CNN) to classify temporal relations between clinical entities and temporal related expressions. To the best of our knowledge, this is the first framework to apply deep learning to temporal information extraction from clinical notes in Chinese EHRs. We conduct extensive sets of experiments on real-world datasets from hospital. The experimental results show the effectiveness of our framework, indicating its practical application value.

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References

  1. Ao, X., Luo, P., Wang, J., Zhuang, F., He, Q.: Mining precise-positioning episode rules from event sequences. IEEE Trans. Knowl. Data Eng. 30(3), 530–543 (2018)

    Article  Google Scholar 

  2. Birkhead, G.S., Klompas, M., Shah, N.R.: Uses of electronic health records for public health surveillance to advance public health. Annu. Rev. Public Health 36, 345–359 (2015)

    Article  Google Scholar 

  3. Chen, X., Zhang, Y., Xu, J., Xing, C., Chen, H.: Deep learning based topic identification and categorization: mining diabetes-related topics on Chinese health websites. In: Navathe, S.B., Wu, W., Shekhar, S., Du, X., Wang, X.S., Xiong, H. (eds.) DASFAA 2016. LNCS, vol. 9642, pp. 481–500. Springer, Cham (2016). https://doi.org/10.1007/978-3-319-32025-0_30

    Chapter  Google Scholar 

  4. Cheng, Y., Anick, P., Hong, P., Xue, N.: Temporal relation discovery between events and temporal expressions identified in clinical narrative. J. Biomed. Inform. 46, S48–S53 (2013)

    Article  Google Scholar 

  5. Cherry, C., Zhu, X., Martin, J.D., de Bruijn, B.: À la recherche du temps perdu: extracting temporal relations from medical text in the 2012 i2b2 NLP challenge. JAMIA 20(5), 843–848 (2013)

    Google Scholar 

  6. Cho, K., et al.: Learning phrase representations using RNN encoder-decoder for statistical machine translation. arXiv preprint arXiv:1406.1078 (2014)

  7. Collobert, R., Weston, J., Bottou, L., Karlen, M., Kavukcuoglu, K., Kuksa, P.: Natural language processing (almost) from scratch. J. Mach. Learn. Res. 12(Aug), 2493–2537 (2011)

    MATH  Google Scholar 

  8. Dligach, D., Miller, T., Lin, C., Bethard, S., Savova, G.: Neural temporal relation extraction. In: Proceedings of the 15th Conference of the European Chapter of the Association for Computational Linguistics, Short Papers, vol. 2, pp. 746–751 (2017)

    Google Scholar 

  9. D’Souza, J., Ng, V.: Temporal relation identification and classification in clinical notes. In: ACM Conference on Bioinformatics, Computational Biology and Biomedical Informatics, ACM-BCB 2013, Washington, DC, USA, 22–25 September 2013, p. 392 (2013). https://doi.org/10.1145/2506583.2506654

  10. Hristovski, D., Dinevski, D., Kastrin, A., Rindflesch, T.C.: Biomedical question answering using semantic relations. BMC Bioinform. 16(1), 6 (2015)

    Article  Google Scholar 

  11. Lafferty, J., McCallum, A., Pereira, F.C.: Conditional random fields: probabilistic models for segmenting and labeling sequence data (2001)

    Google Scholar 

  12. Li, L., Zhang, J., He, Y., Wang, H.: Chinese temporal relation resolution based on Chinese-English parallel corpus. Int. J. Embed. Syst. 9(2), 101–111 (2017)

    Article  Google Scholar 

  13. Lin, C., Miller, T., Dligach, D., Bethard, S., Savova, G.: Representations of time expressions for temporal relation extraction with convolutional neural networks. BioNLP 2017, 322–327 (2017)

    Google Scholar 

  14. Mikolov, T., Sutskever, I., Chen, K., Corrado, G.S., Dean, J.: Distributed representations of words and phrases and their compositionality. In: Advances in Neural Information Processing Systems, pp. 3111–3119 (2013)

    Google Scholar 

  15. Mirza, P., Tonelli, S.: Classifying temporal relations with simple features. In: Proceedings of the 14th Conference of the European Chapter of the Association for Computational Linguistics, pp. 308–317 (2014)

    Google Scholar 

  16. Mishra, R., et al.: Text summarization in the biomedical domain: a systematic review of recent research. J. Biomed. Inform. 52, 457–467 (2014)

    Article  Google Scholar 

  17. Musen, M.A., Middleton, B., Greenes, R.A.: Clinical decision-support systems. In: Shortliffe, E.H., Cimino, J.J. (eds.) Biomedical Informatics: Computer Applications in Health Care and Biomedicine, pp. 643–674. Springer, London (2014). https://doi.org/10.1007/978-1-4471-4474-8_22

    Chapter  Google Scholar 

  18. Palangi, H., et al.: Deep sentence embedding using long short-term memory networks: analysis and application to information retrieval. IEEE/ACM Trans. Audio, Speech Lang. Process. (TASLP) 24(4), 694–707 (2016)

    Article  Google Scholar 

  19. Sun, W., Rumshisky, A., Uzuner, O.: Evaluating temporal relations in clinical text: 2012 i2b2 challenge. J. Am. Med. Inform. Assoc. 20(5), 806–813 (2013)

    Article  Google Scholar 

  20. Tang, B., Wu, Y., Jiang, M., Chen, Y., Denny, J.C., Xu, H.: A hybrid system for temporal information extraction from clinical text. JAMIA 20(5), 828–835 (2013)

    Google Scholar 

  21. Tang, D., Qin, B., Liu, T.: Document modeling with gated recurrent neural network for sentiment classification. In: Proceedings of the 2015 Conference on Empirical Methods in Natural Language Processing, pp. 1422–1432 (2015)

    Google Scholar 

  22. Tourille, J., Ferret, O., Neveol, A., Tannier, X.: Neural architecture for temporal relation extraction: a Bi-LSTM approach for detecting narrative containers. In: Proceedings of the 55th Annual Meeting of the Association for Computational Linguistics, Short Papers, vol. 2, pp. 224–230 (2017)

    Google Scholar 

  23. Wang, J., Wang, Z., Zhang, D., Yan, J.: Combining knowledge with deep convolutional neural networks for short text classification. In: Proceedings of the 26th International Joint Conference on Artificial Intelligence, pp. 2915–2921. AAAI Press (2017)

    Google Scholar 

  24. Xu, Y., Wang, Y., Liu, T., Tsujii, J., Chang, E.I.C.: An end-to-end system to identify temporal relation in discharge summaries: 2012 i2b2 challenge. J. Am. Med. Inform. Assoc. 20(5), 849–858 (2013)

    Article  Google Scholar 

  25. Xu, Y., Wang, Y., Liu, T., Tsujii, J., Chang, E.I.: An end-to-end system to identify temporal relation in discharge summaries: 2012 i2b2 challenge. JAMIA 20(5), 849–858 (2013)

    Google Scholar 

  26. Zhang, Y., Li, X., Wang, J., Zhang, Y., Xing, C., Yuan, X.: An efficient framework for exact set similarity search using tree structure indexes. In: 2017 IEEE 33rd International Conference on Data Engineering (ICDE), pp. 759–770. IEEE (2017)

    Google Scholar 

  27. Zheng, X., Li, P., Huang, Y., Zhu, Q.: An approach to recognize temporal relations between Chinese events. In: Lu, Q., Gao, H. (eds.) Chinese Lexical Semantics. LNCS (LNAI), vol. 9332, pp. 543–553. Springer, Cham (2015). https://doi.org/10.1007/978-3-319-27194-1_55

    Chapter  Google Scholar 

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Acknowledgement

Our work is supported by NSFC (91646202), the National High-tech R&D Program of China (SS2015AA020102), Research/Project 2017YB142 supported by Ministry of Education of The People’s Republic of China, the 1000-Talent program, Tsinghua University Initiative Scientific Research Program.

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Correspondence to Chunxiao Xing .

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Tian, B., Xing, C. (2018). Deep Learning Based Temporal Information Extraction Framework on Chinese Electronic Health Records. In: Meng, X., Li, R., Wang, K., Niu, B., Wang, X., Zhao, G. (eds) Web Information Systems and Applications. WISA 2018. Lecture Notes in Computer Science(), vol 11242. Springer, Cham. https://doi.org/10.1007/978-3-030-02934-0_19

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  • DOI: https://doi.org/10.1007/978-3-030-02934-0_19

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