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Meta-analysis of the Immunomodulatory Effect of Ganoderma Lucidum Spores Using an Automatic Pipeline

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Smart Health (ICSH 2018)

Part of the book series: Lecture Notes in Computer Science ((LNISA,volume 10983))

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Abstract

Although many studies have been conducted on the chemistry and pharmacological activities of Ganoderma lucidum spores (GLS), there is a lack of systematic review on the health promoting functions especially immunomodulatory effects of GLS. In the current study, we constructed a data model and utilized R modules and PERL language to implement a pipeline that is capable of carrying out multiple meta-analyses automatically. Using GLS as the study subject, we carried out meta-analyses on 53 outcome measures using the automatic meta-analysis pipeline. Among them, 19 outcome measures were found to be significantly affected after GLS treatment (with p value < 0.05). 8 of them have I^2 less than 50%, indicating low level of study heterogeneity. Through the analysis of GLS, the automatic meta-analysis pipeline has been shown to be suitable for high-throughput meta-analysis and visualization. Also, the information derived from this study could assist policy-makers and functional food consumers to determine whether GLS could be a recommended choice for immunomodulatory effect.

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Acknowledgement

This work was supported by grants from CAMS Innovation Fund for Medical Sciences (CIFMS) (2016-I2M-3-016 and 2017-I2M-1-013), From the Chinese Academy of Medical Science.

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Authors and Affiliations

  1. Central China Normal University, 152 Luoyu Road, 430079, Wuhan, China

    Rui Liu, Yumeng Zhang, Ziwen Chen & Guifeng Hua

  2. Institute of Medicinal Plant Development, Chinese Academy of Medical Science, 151 Malianwa North Road, 100193, Beijing, China

    Liqiang Wang, Shuaibing He & Chang Liu

Authors
  1. Rui Liu
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  2. Yumeng Zhang
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  3. Ziwen Chen
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  4. Liqiang Wang
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  5. Shuaibing He
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  6. Guifeng Hua
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  7. Chang Liu
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Correspondence to Chang Liu .

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Editors and Affiliations

  1. University of Arizona, Tucson, AZ, USA

    Hsinchun Chen

  2. Wuhan University, Wuhan, China

    Qing Fang

  3. University of Arizona, Tucson, AZ, USA

    Daniel Zeng

  4. Wuhan University, Wuhan, China

    Jiang Wu

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Liu, R. et al. (2018). Meta-analysis of the Immunomodulatory Effect of Ganoderma Lucidum Spores Using an Automatic Pipeline. In: Chen, H., Fang, Q., Zeng, D., Wu, J. (eds) Smart Health. ICSH 2018. Lecture Notes in Computer Science(), vol 10983. Springer, Cham. https://doi.org/10.1007/978-3-030-03649-2_33

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  • DOI: https://doi.org/10.1007/978-3-030-03649-2_33

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-03648-5

  • Online ISBN: 978-3-030-03649-2

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