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A Nano Communication System for CTC Detection in Blood Vessels

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Computational Intelligence Methods for Bioinformatics and Biostatistics (CIBB 2017)

Part of the book series: Lecture Notes in Computer Science ((LNBI,volume 10834))

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Abstract

In this paper, we show a simulation scenario of a short section of a blood vessel, in which white blood cells, red blood cells, and platelets move as a consequence of collisions and the Hagen–Poiseuille law. In addition to these cells, we have considered also the presence of circulating tumor cells (CTC) and of a receiver node that is able to detect the presence of CTC by using its surface receptors which are affine to the ligands present on the CTC surface.

This study aims at identifying potential optimal positions of CTC sensors within blood vessels in order to maximize the probability of a successful detection.

A simulation campaign has been performed by the BiNS2 simulation framework for several distances of the receiver node from the vessel axis. Obtained results show that CTCs tend to move towards the endothelium.

Supported by the EU project H2020 FET Open CIRCLE (Coordinating European Research on Molecular Communications, project No. 665564) and by the MolML project funded by University of Perugia.

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Authors and Affiliations

  1. Department of Engineering, University of Perugia, CNIT RU, Via G. Duranti 93, 06125, Perugia, Italy

    Luca Felicetti, Mauro Femminella & Gianluca Reali

Authors
  1. Luca Felicetti
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  2. Mauro Femminella
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  3. Gianluca Reali
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Corresponding author

Correspondence to Mauro Femminella .

Editor information

Editors and Affiliations

  1. University of Cagliari, Cagliari, Italy

    Massimo Bartoletti

  2. University of Genova, Genoa, Italy

    Annalisa Barla

  3. University of Stirling, Stirling, UK

    Andrea Bracciali

  4. Heinrich-Heine-University DĂĽsseldorf, DĂĽsseldorf, Germany

    Gunnar W. Klau

  5. Houston Methodist Research Institute, Houston, TX, USA

    Leif Peterson

  6. University of Udine, Udine, Italy

    Alberto Policriti

  7. University of Salerno, Fisciano, Italy

    Roberto Tagliaferri

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Felicetti, L., Femminella, M., Reali, G. (2019). A Nano Communication System for CTC Detection in Blood Vessels. In: Bartoletti, M., et al. Computational Intelligence Methods for Bioinformatics and Biostatistics. CIBB 2017. Lecture Notes in Computer Science(), vol 10834. Springer, Cham. https://doi.org/10.1007/978-3-030-14160-8_16

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  • DOI: https://doi.org/10.1007/978-3-030-14160-8_16

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-14159-2

  • Online ISBN: 978-3-030-14160-8

  • eBook Packages: Computer ScienceComputer Science (R0)

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