Skip to main content

Providing Alternative Measures for Addressing Adverse Drug-Drug Interactions

  • Conference paper
  • First Online:
New Knowledge in Information Systems and Technologies (WorldCIST'19 2019)

Part of the book series: Advances in Intelligent Systems and Computing ((AISC,volume 931))

Included in the following conference series:

Abstract

Clinical Practice Guidelines (CPGs) are documents used in daily clinical practice that provide advice on how to best diagnose and treat diseases in the form of a list of clinical recommendations. When simultaneously applying multiple CPGs to patients, this can lead to complex multiple drug regimens (polypharmacy) with the potential for harmful combinations of drugs. The need to address these adverse drug events calls forth for systems capable of not only automatically represent the common potential conflicts or interactions that can happen when merging CPGs but also systems capable of providing conflict-free alternatives. This paper presents a solution that represents CPGs as Computer-Interpretable Guidelines (CIGs) and allows the automatic identification of drug conflicts and the provision of alternative measures to resolve these conflicts.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Aschner, P.: New IDF clinical practice recommendations for managing type 2 diabetes in primary care (2017)

    Google Scholar 

  2. Boyd, C.M., Darer, J., Boult, C., Fried, L.P., Boult, L., Wu, A.W.: Clinical practice guidelines and quality of care for older patients with multiple comorbid diseases: implications for pay for performance. JAMA 294(6), 716–724 (2005)

    Article  Google Scholar 

  3. Dolan, J.G., Boohaker, E., Allison, J., Imperiale, T.F.: Patients’ preferences and priorities regarding colorectal cancer screening. Med. Decis. Making 33(1), 59–70 (2013)

    Article  Google Scholar 

  4. Gonçalves, F., Oliveira, T., Neves, J., Novais, P.: Compguide: acquisition and editing of computer-interpretable guidelines. In: World Conference on Information Systems and Technologies, pp. 257–266. Springer (2017)

    Google Scholar 

  5. Jafarpour, B., Abidi, S.S.R.: Merging disease-specific clinical guidelines to handle comorbidities in a clinical decision support setting. In: Conference on Artificial Intelligence in Medicine in Europe, pp. 28–32. Springer (2013)

    Google Scholar 

  6. Kennedy, C., Brewer, L., Williams, D.: Drug interactions. Medicine (United Kingdom) 44(7), 422–426 (2016), http://dx.doi.org/10.1016/j.mpmed.2016.04.015

    Article  Google Scholar 

  7. Liu, S., Ma, W., Moore, R., Ganesan, V., Nelson, S.: Rxnorm: prescription for electronic drug information exchange. IT Prof. 7(5), 17–23 (2005)

    Article  Google Scholar 

  8. López-Vallverdú, J.A., Riaño, D., Collado, A.: Rule-based combination of comorbid treatments for chronic diseases applied to hypertension, diabetes mellitus and heart failure. In: Process Support and Knowledge Representation in Health Care, pp. 30–41. Springer (2013)

    Google Scholar 

  9. Mohler, J.L., Lee, R.T., Antonarakis, E.S., Armstrong, A.J., D’Amico, A.V., Davis, B.J., Dorf, T., Eastham, J.A., Ellis, R., Enke, C.A., Farrington, T.A.: National Comprehensive Cancer Network - Prostate Cancer. Technical report, National Comprehensive Cancer Network (2018). http://linkinghub.elsevier.com/retrieve/pii/B9780323358682000803

  10. Oliveira, T., Novais, P., Neves, J.: Representation of clinical practice guideline components in owl. In: Trends in Practical Applications of Agents and Multiagent Systems, pp. 77–85. Springer (2013)

    Google Scholar 

  11. Oliveira, T., Silva, A., Neves, J., Novais, P.: Decision support provided by a temporally oriented health care assistant. J. Med. Syst. 41(1), 13 (2017)

    Google Scholar 

  12. Phillips, L.D., Fasolo, B., Zafiropoulos, N., Beyer, A.: Is quantitative benefit-risk modelling of drugs desirable or possible? Drug Discov. Today Technol. 8(1), e3–e10 (2011)

    Article  Google Scholar 

  13. Wilk, S., Michalowski, M., Michalowski, W., Rosu, D., Carrier, M., Kezadri-Hamiaz, M.: Comprehensive mitigation framework for concurrent application of multiple clinical practice guidelines. J. Biomed. Inform. 66, 52–71 (2017)

    Article  Google Scholar 

  14. Zamborlini, V., Da Silveira, M., Pruski, C., ten Teije, A., Geleijn, E., van der Leeden, M., Stuiver, M., van Harmelen, F.: Analyzing interactions on combining multiple clinical guidelines. Artif. Intell. Med. 81, 78–93 (2017)

    Article  Google Scholar 

Download references

Acknowledgements

This work has been supported by COMPETE: POCI-01-0145-FEDER-0070 43 and FCT – Fundação para a Ciência e Tecnologia within the Project Scope UID/CEC/ 00319/2013. The work of Tiago Oliveira was supported by JSPS KAKENHI Grant Number JP18K18115.

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to António Silva , Tiago Oliveira , Ken Satoh or Paulo Novais .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Silva, A., Oliveira, T., Satoh, K., Novais, P. (2019). Providing Alternative Measures for Addressing Adverse Drug-Drug Interactions. In: Rocha, Á., Adeli, H., Reis, L., Costanzo, S. (eds) New Knowledge in Information Systems and Technologies. WorldCIST'19 2019. Advances in Intelligent Systems and Computing, vol 931. Springer, Cham. https://doi.org/10.1007/978-3-030-16184-2_54

Download citation

Publish with us

Policies and ethics