Skip to main content

Psychiatric Disorders Classification with 3D Convolutional Neural Networks

  • Conference paper
  • First Online:
Recent Advances in Big Data and Deep Learning (INNSBDDL 2019)

Part of the book series: Proceedings of the International Neural Networks Society ((INNS,volume 1))

Included in the following conference series:

Abstract

Recently, the literature showed that psychiatric disorders, such as Schizophrenia and Bipolar disorder, cause abnormalities in some brain regions. Therefore, several automatic mechanisms based on classical Machine Learning techniques have been used to recognize these diseases by means of the study of neuroimaging. A serious drawback of these approaches is that they consider only the intensity value of the points from neuroimages, without taking into account the spatiality information. Convolutional Neural Networks have subsequently applied to overcome the aforementioned issue, showing their empirical effectiveness on these tasks. However, generally Convolutional Neural Networks operate on 2D slices of the brain instead of the whole 3D structure.

This work aims to analyze the behavior of classical machine learning techniques against 2D and novel 3D Convolutional Neural Network models. An exhaustive empirical assessment has been performed to evaluate these methods on 4 real-world neuroimaging tasks, including Schizophrenia and Bipolar Disorder classification.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Statistical Parametric Mapping. http://www.fil.ion.ucl.ac.uk/spm/

  2. Abraham, A., Pedregosa, F., Eickenberg, M., Gervais, P., Mueller, A., Kossaifi, J., Gramfort, A., Thirion, B., Varoquaux, G.: Machine learning for neuroimaging with scikit-learn. Front. Neuroinform. 8, 14 (2014)

    Article  Google Scholar 

  3. Ashburner, J., Friston, K.J.: Voxel-based morphometry–the methods. Neuroimage 11(6), 805–821 (2000)

    Article  Google Scholar 

  4. Bledsoe, J.C., Xiao, D., Chaovalitwongse, A., Mehta, S., Grabowski, T.J., Semrud-Clikeman, M., Pliszka, S., Breiger, D.: Diagnostic classification of ADHD versus control: support vector machine classification using brief neuropsychological assessment. J. Atten. Disord. 1087054716649666 (2016)

    Google Scholar 

  5. Fan, Y., Resnick, S.M., Wu, X., Davatzikos, C.: Structural and functional biomarkers of prodromal Alzheimer’s disease: a high-dimensional pattern classification study. Neuroimage 41(2), 277–285 (2008)

    Article  Google Scholar 

  6. Gao, X.W., Hui, R.: A deep learning based approach to classification of CT brain images. In: SAI Computing Conference (SAI), pp. 28–31. IEEE (2016)

    Google Scholar 

  7. LeCun, Y., et al.: LeNet-5, Convolutional Neural Networks, p. 20 (2015). http://yann.lecun.com/exdb/lenet

  8. Matsugu, M., Mori, K., Mitari, Y., Kaneda, Y.: Subject independent facial expression recognition with robust face detection using a convolutional neural network. Neural Netw. 16(5–6), 555–559 (2003)

    Article  Google Scholar 

  9. Milletari, F., Navab, N., Ahmadi, S.A.: V-Net: fully convolutional neural networks for volumetric medical image segmentation. In: 2016 Fourth International Conference on 3D Vision (3DV), pp. 565–571. IEEE (2016)

    Google Scholar 

  10. Orru, G., Pettersson-Yeo, W., Marquand, A.F., Sartori, G., Mechelli, A.: Using support vector machine to identify imaging biomarkers of neurological and psychiatric disease: a critical review. Neurosci. Biobehav. Rev. 36(4), 1140–1152 (2012)

    Article  Google Scholar 

  11. Payan, A., Montana, G.: Predicting Alzheimer’s disease: a neuroimaging study with 3d convolutional neural networks. arXiv preprint arXiv:1502.02506 (2015)

  12. Ronneberger, O., Fischer, P., Brox, T.: U-Net: convolutional networks for biomedical image segmentation. In: International Conference on Medical Image Computing and Computer-Assisted Intervention, pp. 234–241. Springer (2015)

    Google Scholar 

  13. Sarraf, S., Tofighi, G.: Classification of Alzheimer’s disease using fMRI data and deep learning convolutional neural networks. arXiv preprint arXiv:1603.08631 (2016)

  14. Scarpazza, C., De Simone, M.S.: Voxel-based morphometry: current perspectives. Neurosci. Neuroecon. 5, 19–35 (2016)

    Article  Google Scholar 

  15. Schnack, H.G., Nieuwenhuis, M., van Haren, N.E., Abramovic, L., Scheewe, T.W., Brouwer, R.M., Pol, H.E.H., Kahn, R.S.: Can structural mri aid in clinical classification? A machine learning study in two independent samples of patients with schizophrenia, bipolar disorder and healthy subjects. Neuroimage 84, 299–306 (2014)

    Article  Google Scholar 

  16. Shioya, A., Saito, Y., Arima, K., Kakuta, Y., Yuzuriha, T., Tanaka, N., Murayama, S., Tamaoka, A.: Neurodegenerative changes in patients with clinical history of bipolar disorders. Neuropathology 35(3), 245–253 (2015)

    Article  Google Scholar 

  17. Vieira, S., Pinaya, W.H., Mechelli, A.: Using deep learning to investigate the neuroimaging correlates of psychiatric and neurological disorders: methods and applications. Neurosci. Biobehav. Rev. 74, 58–75 (2017)

    Article  Google Scholar 

  18. Zipursky, R.B., Reilly, T.J., Murray, R.M.: The myth of schizophrenia as a progressive brain disease. Schizophr. Bull. 39(6), 1363–1372 (2012)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ivano Lauriola .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Campese, S., Lauriola, I., Scarpazza, C., Sartori, G., Aiolli, F. (2020). Psychiatric Disorders Classification with 3D Convolutional Neural Networks. In: Oneto, L., Navarin, N., Sperduti, A., Anguita, D. (eds) Recent Advances in Big Data and Deep Learning. INNSBDDL 2019. Proceedings of the International Neural Networks Society, vol 1. Springer, Cham. https://doi.org/10.1007/978-3-030-16841-4_6

Download citation

Publish with us

Policies and ethics