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A Prediction Method of DNA-Binding Proteins Based on Evolutionary Information

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Intelligent Computing Theories and Application (ICIC 2019)

Part of the book series: Lecture Notes in Computer Science ((LNISA,volume 11644))

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Abstract

DNA is the carrier of genetic information in organisms, and DNA-binding protein is one type of unwinding enzymes, which plays a key role in various biological molecular functions. That has greatly promoted the research of various methods for identifying DNA-binding proteins. In recent years, researchers have developed a Machine Learning-based method to predict DNA-binding proteins quickly and accurately. Although the prediction accuracy of current methods is considerable, the performance of their prediction can be further improved. In this paper, a DNA-binding proteins prediction model based on PSSM (Position Specific Scoring Matrix) features and Random Forest classifier is proposed. The results of experiments show that the proposed method can achieve great prediction performance on PDB1075 and PDB186 datasets, whose accuracy is 82.14% and 79.0%, respectively. Experiments show that the method can be compared with other methods, and even surpass the previous methods on some datasets.

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Acknowledgements

This paper is supported by the National Natural Science Foundation of China (61772357, 61502329, 61672371, and 61876217), Jiangsu Province 333 Talent Project, Top Talent Project (DZXX-010), Suzhou Foresight Research Project (SYG201704, SNG201610, and SZS201609).

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Authors and Affiliations

  1. School of Electronic and Information Engineering, Suzhou University of Science and Technology, Suzhou, 215009, China

    Weizhong Lu, Zhengwei Song, Yijie Ding, Hongjie Wu & Hongmei Huang

  2. Suzhou Key Laboratory of Virtual Reality Intelligent Interaction and Application Technology, Suzhou University of Science and Technology, Suzhou, 215009, China

    Weizhong Lu, Yijie Ding & Hongjie Wu

Authors
  1. Weizhong Lu
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  2. Zhengwei Song
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  3. Yijie Ding
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  4. Hongjie Wu
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  5. Hongmei Huang
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Corresponding author

Correspondence to Yijie Ding .

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Editors and Affiliations

  1. Tongji University, Shanghai, China

    De-Shuang Huang

  2. University of Ulsan, Ulsan, Korea (Republic of)

    Kang-Hyun Jo

  3. Nanchang Institute of Technology, Nanchang, China

    Zhi-Kai Huang

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Lu, W., Song, Z., Ding, Y., Wu, H., Huang, H. (2019). A Prediction Method of DNA-Binding Proteins Based on Evolutionary Information. In: Huang, DS., Jo, KH., Huang, ZK. (eds) Intelligent Computing Theories and Application. ICIC 2019. Lecture Notes in Computer Science(), vol 11644. Springer, Cham. https://doi.org/10.1007/978-3-030-26969-2_40

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  • DOI: https://doi.org/10.1007/978-3-030-26969-2_40

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-26968-5

  • Online ISBN: 978-3-030-26969-2

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