Abstract
Coronary dysfunction is one of the most common coronary diseases in people living in highly developed regions of the world, where heart infarction and sudden cardiac death often result from stenosis. Besides symptomatic treatment of ischaemic heart diseases, invasive methods are also used. An effective form of aid in the case of ischaemic heart diseases resulting from coronary stenosis and/or heart infarction is mechanical heart assistance provided by an intra-aortic balloon pump (IABP). Therefore, the main goal of this paper was to elaborate a sophisticated computer model of the coronary circulation (CCM) to enable coronary system pathological states modeling such as coronary stenosis. This coronary model must be executed in the real-time and be suitable to be used in the hybrid (hydraulic-numerical) cardiovascular simulator. CCM consists of 4 main coronary arteries modeled by series of resistance-inertance-compliance compartments: left main artery (LCA), right main artery including intraventricular hind branch, left main circumflex artery, left anterior descending artery. The peripheral coronary circulation was modeled by an intramyocardial pump model. An innovative feature introduced in CCM is a physiological model between the coronary circulation and the end systolic pressure volume relationship function of the ventricles. CCM was integrated with the whole, closed-loop model of the cardiovascular system. Exemplary simulation results at rest and myocardial hyperemia conditions as well as for LCA stenosis are consistent with the physiology and literature. As a part of the hybrid cardiovascular simulator CCM can be exploited in simulation scenarios of IABP assistance by real, physical balloon.
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The study received financial support from the Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences
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Zieliński, K., Górczyńska, K., Kozarski, M., Okrzeja, P., Darowski, M., Ferrari, G. (2020). A Novel Real-Time Computer Model of the Coronary System Including a Physiological Feedback Between the Left Ventricular Muscles and Coronary Perfusion. In: Korbicz, J., Maniewski, R., Patan, K., Kowal, M. (eds) Current Trends in Biomedical Engineering and Bioimages Analysis. PCBEE 2019. Advances in Intelligent Systems and Computing, vol 1033. Springer, Cham. https://doi.org/10.1007/978-3-030-29885-2_24
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DOI: https://doi.org/10.1007/978-3-030-29885-2_24
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